Abstract：Objective To explore the application effect of sequential descending continuous femoral nerve block in patients undergoing total knee arthroplasty.Methods A total of 80 patients undergoing total knee arthroplasty under combined spinal and epidural anesthesia in Dalian Friendship Hospital from July 2019 to June 2020 were selected as the research objects and divided into the observation group and the control group according to random number table method,with 40 cases in each group.Patients in the observation group received sequential descending continuous femoral nerve block,and patients in the control group received continuous drug controlled analgesia.Visual analogue scale (VAS) score,substance P (SP) level,knee joint international knee scoring committee (IKDC) score and complications were compared between the two groups during treatment.Results The pain VAS scores of observation group were lower than those of the control group at 12,24 and 48 h after surgery,and the differences were statistically significant(P＜0.05).The levels of SP in observation group were lower than those of the control group at 12,24 and 48 h after operation,and the differences were statistically significant (P＜0.05).At 48 h after surgery,knee IKDC scores of the two groups were higher than those at 6 h after surgery,and the differences were statistically significant (P＜0.05).The knee IKDC score of the observation group 48 h after surgery was higher than that of the control group,and the difference was statistically significant (P＜0.05).The total incidence of skin itching,lower limb numbness,constipation and hematoma in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion For patients undergoing total knee arthroplasty,sequential descending femoral nerve block can effectively improve postoperative pain and knee function,with fewer complications and high safety.
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