Objective To explore and analyze the application effect of bracketless invisible appliance in orthodontic treatment.Methods A total of 50 orthodontic patients admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from June 2018 to June 2019 were selected as the research subjects.They were divided into observation group and control group by computer random drawing method,with 25 cases in each group.Patients in the observation group were treated with bracketless invisible appliance,and patients in the control group were treated with MBT metal bracket straight wire appliance.The periodontal index(gingival index[GI],plaque index[PLI],gingival crevicular bleeding index[SBI],gingival crevicular depth[SPD])of the two groups were compared.The satisfaction scores of dental aesthetics,social interaction,comfort,oral hygiene,psychological disorders,correction process,quality of life and the number of visits were compared between the two groups.The adverse reaction scores of oral ulcer,tooth pain and masticatory difficulty were compared between the two groups.Results After 6 months of treatment,GI,PLI and SBI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in SPD between the two groups after 6 months of treatment(P>0.05).After 12 months of treatment,the satisfaction scores of patients in dental aesthetics,social interaction,comfort,oral hygiene,psychological disorders,correction process,quality of life and the number of visits in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The adverse reaction score of oral ulcer,tooth pain and masticatory difficulty in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).Conclusion In the clinical orthodontic treatment,the bracketless invisible appliance has a definite effect and significant clinical application value.