Abstract：Glioma is a primary malignant tumor of nervous system,accounting for about 40% of all brain tumors and 80% of brain malignant tumors,and it is easy to relapse.At present,World Health Organization(WHO)divides gliomas into four grades,of which gradeⅠ-Ⅱare low-grade gliomas,including diffuse astrocytoma,pilocytic astrocytoma,etc.,while gradeⅢ-Ⅳis high-grade glioma,which has a higher degree of malignancy,such as glioblastoma,anaplastic astrocytoma,etc.Most of the high-grade gliomas will recur in a short time after treatment,and the recurrence rate is high,which will invade multiple cerebral lobes and cause brain metastasis.The short-term mortality of recurrent highgrade glioma is high.How to effectively improve the treatment effect is the focus of clinical research.In order to pay more attention to recurrent high-grade glioma and improve its therapeutic effect,a large number of literatures on clinical treatment of recurrent high-grade glioma in recent five years were reviewed.After eliminating the unreasonable data and insufficient empirical evidence,the treatment progress of recurrent high-grade glioma was summarized,so as to provide clinical reference and reference.
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