Research progress of biomarkers in early diagnosis of diabetic nephropathy
JI Chao1 SONG Yu-ling2 LIU Chang-mei
1.College of Clinical Medicine, Binzhou Medical University, Shandong Province, Binzhou 256603, China;
2.Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Shandong Province, Binzhou 256603,China
Abstract：Diabetic nephropathy (DN), defined as urinary albumin excretion rate (UAER) >300 mg/24 h and declining renal function in a patient with known diabetes mellitus (DM) in the absence of urinary tract infection or any other renal diseases.DN is a common microvascular complication of DM.Searching for biomarkers with high sensitivity and specificity is helpful for early diagnosis and treatment of DN to improve the prognosis of patients.In order to provide researchers with the current research status of DN, this paper will summarize and discuss the research progress of biomarkers in the early diagnosis of DN based on glomerular and tubular injury, oxidative stress, inflammation and proteomics, hoping that biomarkers can be used in clinical work as soon as possible.
纪超；宋玉玲；刘长梅. 生物学标志物在糖尿病肾病早期诊断中的研究进展[J]. 中国当代医药, 2021, 28(10): 36-39.
JI Chao；SONG Yu-ling； LIU Chang-mei. Research progress of biomarkers in early diagnosis of diabetic nephropathy. 中国当代医药, 2021, 28(10): 36-39.
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