Abstract：Objective To observe the clinical effect of Remifentanil combined with Propofol on painless gastroscopy anesthesia. Methods A total of 100 patients who underwent painless gastroenteroscopy and treatment in our hospital from October 2017 to August 2018 were selected. According to the random numer table method, they were divided into two groups with 50 patients in each group. Group A (experimental group) was anesthetized with Remifentanil 0.3-0.5 μg/kg combined with Propofol. Group B (control group) was given Propofol 1.5-2.0 mg/kg to complete the operation. The mean arterial pressure, heart rate, Propofol dosage, gastroenteroscopy time, waking time, anesthetic effect, and adverse reactions of the two groups were observed and compared. Results There were no significant differences in mean arterial pressure and heart rate between the two groups (P＞0.05). Propofol dosage in group A was less than that in group B,with statistically significant difference(P＜0.05).The recovery time of patients in group A was shorter than that in group B,the difference was statistically significant (P＜0.05). There was no significant difference between the two groups in gastrointestinal endoscopy and the time of patients leaving hospital after awake (P＞0.05). The excellent rate of anesthesia effect in group A was higher than that in group B, the difference was statistically significant (P＜0.05). The occurrence rate of respiratory depression in group A was lower than that in group B, the difference was statistically significant (P＜0.05). There was no significant difference in the occurrence rate of postoperative nausea, vomiting, vertigo between the two groups (P＞0.05). Conclusion Remifentanil combined with Propofol for painless gastrointestinal endoscopy anesthesia reduces the dosage of Propofol, shortens the recovery time of patients, has fewer adverse reactions, and is safe and effective in clinical use.
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