Abstract：Objective To analyze the application value of MR diffusion kurtosis imaging（DKI）in the microstructural changes of the frontal cortex of patients with mild cognitive impairment（MCI）.Methods The clinical data of 93 patients with cerebral small vessel disease treated in our hospital from May 2018 to April 2019 were retrospectively analyzed.Among them，45 patients without MCI were selected as the control group，and 48 patients with MCI were selected as the observation group.Both groups received regular MR and DKI scanning.The mean kurtosis（MK），axial kurtosis（AK），and diffusion fraction anisotropy（FA）values of the two groups in interest area were compared.Results The MK of the right anterior and side cingulate cerebral gyrus of the observation group was（0.66±0.08）mm2/s，AK was（0.63±0.07）mm2/s，and FA was（0.16±0.04）mm2/s，which lower than those in the control group for（0.72±0.05），（0.69±0.05），（0.19±0.02）mm2/s，respectively，and the differences were statistically significant（P＜0.05）.There were no significant differences in the MK，AK and FA values of the left anterior cingulate and side cingulate cerebral gyrus and the bilateral dorsolateral gyrus between the two groups（P＞0.05）.Conclusion DKI technology can be used as an effective way to observe the microstructural changes of the frontal cortex in patients with MCI，and the MK，AK，FA parameters can provide important information for clinical evaluation.
王庆波； 赵阳； 王家富. MR扩散峰度成像技术在轻度认知功能障碍患者额叶前皮质微结构变化中的应用价值[J]. 中国当代医药, 2020, 27(4): 180-182.
WANG Qing-bo； ZHAO Yang； WANG Jia-fu. Application value of MR diffusion kurtosis imaging in the microstructural changes of frontal cortex in patients with mild cognitive impairment. 中国当代医药, 2020, 27(4): 180-182.
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