Abstract：Objective To explore the clinical application effect of interventional therapy on patients with lower extremity arteriosclerosis obliterans.Methods A total of 126 patients with lower extremity arteriosclerosis obliterans treated in our hospital from December 2015 to December 2018 were selected as research subjects.They were divided into control group (n=63) and observation group (n=63) by random number table method.Patients in the control group were treated with conventional drug therapy, and patients in the observation group were treated with interventional therapy.The hemodynamic indicators (erythrocyte sedimentation rate, fibrinogen, plasma viscosity and whole blood viscosity), ultrasound findings (middle layer thickness of carotid intima, ankle brachial index and conduction velocity of pulse wave),improvement time of disease (relief time of limb cold, rest pain and intermittent claudication and hospitalization time),clinical effect, sequelae (epilepsy, cerebral palsy and neurodevelopmental retardation) of the two groups were compared.Results After treatment, the erythrocyte sedimentation rate, fibrinogen, plasma viscosity, whole blood viscosity, middle layer thickness of carotid intima and conduction velocity of pulse wave in the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05).The ankle brachial index of the two groups after treatment was higher than that before treatment, and the difference was statistically significant (P＜0.05).After treatment, the erythrocyte sedimentation rate, fibrinogen, plasma viscosity, whole blood viscosity, middle layer thickness of carotid intima and conduction velocity of pulse wave in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The ankle brachial index of the observation group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05).The relief time of limb cold,rest pain and intermittent claudication and hospitalization time in the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).The total effective rate of treatment in the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total incidence of sequelae in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Interventional treatment has a remarkable therapeutic effect on lower extremity arteriosclerosis obliterans.It can improve the hemodynamic status and shorten the time of treatment.
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