Objective To investigate the application effect of ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia in radical resection of colorectal cancer.Methods A total of 70 cases of patients who underwent radical colorectal cancer treatment from January 2015 to July 2016 in our hospital were selected as the research subjects.According to the random number table method, they were divided into the observation group and the control group, 35 cases in the each group.The control group was selected under general anesthesia, the observation group was selected ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia.The effects of anesthesia, the amount of general anesthetic drugs during the operation, vital signs indicators and the recovery time of postoperative consciousness were compared between the two groups.Results There was no significant difference in the excellent and good rate of anesthesia between the two groups (P＞0.05).The dosage of Propofol and Sufentanil in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the duration of anesthesia between the two groups (P＞0.05).There were no significant differences in the heart rate and mean arterial pressure of the two groups between before and after anesthesia (P＞0.05).The recovery time of eyes opening, swallowing reflex and orientation force in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia can reduce the dosage of general anesthesia drugs and accelerate the recovery of postoperative consciousness on the premise of ensuring the anesthesia effect and duration of colorectal cancer radical operation.