Objective To explore the clinical effect of Bifidobacterium Triple Living Bacteria Powder combined with Montmorillonite Powder in the treatment of infantile diarrhea.Methods A total of 80 children with diarrhea treated in our hospital from January 2018 to October 2019 were selected and divided into Montmorillonite Powder group (n=40)and Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group (n=40).Group were treated with Montmorillonite Powder combined with Triple Live Bacteria Powder The children in the Montmorillonite Powder combined with Triple Live Bacteria Powder.The curative effect of diarrhea was compared between the two groups;the time for stool characteristics to return to normal state, the time for stool defecation times to reach normal range, the time for body temperature to return to normal range, the score of diarrhea symptoms, nutritional index and adverse drug reactions before and after treatment were compared.Results The curative effect of diarrhea in the Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group was higher than that in the Montmorillonite Powder group, the difference was statistically significant (P<0.05).The time for stool character to return to normal state, the time for defecation frequency to reach normal range and the time for body temperature to return to normal range in Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group were shorter than those in Montmorillonite Powder group, and the differences were statistically significant (P<0.05).The score of diarrhea symptoms in the Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group was lower than that in the Montmorillonite Powder group, and the nutritional index was higher than that in the Montmorillonite Powder group, and the differences were statistically significant (P<0.05).There was no significant difference in adverse drug reaction between the two groups (P＞0.05).Conclusion Montmorillonite powder combined with Bifidobacterium Triple Live Bacteria Powder is effective in the treatment of diarrhea, compared with Montmorillonite Powder,Montmorillonite Powder can effectively improve diarrhea and nutritional status with high safety and no serious adverse reactions.