Abstract：Objective To compare the clinical effect of Didroxyprogesterone and Progesterone Injection in the treatment of threatened abortion. Methods A total of 50 cases of threatened abortion patients admitted to our hospital from January 2018 to January 2019 were selected as the research objects. According to the method of random number table,they were divided into observation group and control group, with 25 cases in each group. The observation group was treated with Didroxyprogesterone orally, while the control group was treated with Progesterone Injection. The clinical symptom relief time, hormone level, success rate of fetal protection and adverse reactions of the two groups were compared. Results The relieving time of lumbago, abdominal pain and hemostasis in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). Two weeks after treatment, the progesterone (P) and estradiol (E2) in the observation group were lower than those in the control group, and the levels of chorionic gonadotropin (HCG) were higher than those in the control group, the levels of P, E2 and HCG were lower than those in the control group at 4 weeks after treatment, with statistically significant differences (P＜0.05). The materni success rate of the observation group which was higher than that in the control group, with statistically significant difference (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with statistically significant difference (P＜0.05). Conclusion The clinical effect of Dydrogesterone on threatened abortion is better than Progesterone Injection.
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