3.0T磁共振T1WI与T1 mapping在轻度新生儿高胆红素血症诊断中的临床价值

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摘要目的探讨3.0T 磁共振T1WI 与T1 mapping 在轻度新生儿高胆红素血症诊断中的临床价值。方法选取2018年7月～2019年1月深圳市龙华区人民医院新生儿科收治的13 例轻度高胆红素血症患儿作为高胆组，另选取同期的17 例正常新生儿作为正常组。利用飞利浦3.0T 磁共振对高胆组和正常组新生儿行常规T1WI 和T1 mapping 序列。通过后处理工作站测量其双侧苍白球区域T1 信号强度并计算平均值。采用8 个不同反转时间的IR-TSE 序列，通过自动运算得到T1 mapping 图，测量双侧苍白球区域的T1 值并计算其平均值。比较两组的T1信号强度和T1 值差异，并分别对苍白球的T1 信号强度和T1 值与血清总胆红素峰值进行相关性分析。结果高胆组的血清总胆红素峰值高于正常组，差异有统计学意义（P＜0.05）；高胆组的苍白球T1 信号强度高于正常组，差异有统计学意义（P＜0.05）。高胆组的苍白球T1 值低于正常组，差异有统计学意义（P＜0.05）。苍白球T1 信号强度与血清总胆红素峰值成正相关（r=0.675，P=0.000），苍白球T1 值与血清总胆红素峰值成轻度负相关（r=-0.455，P=0.012）。结论轻度新生儿高胆红素血症患儿苍白球的T1 信号强度和T1 值与正常新生儿存在差异性，对早期急性胆红素脑病的诊断具有提示意义。

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	丁玲
	杜江齐
	曾剑兵
	王新正

关键词 ：新生儿黄疸, T1 信号强度, T1 值, T1 mapping

Abstract：Objective To investigate the clinical value of T1WI and T1 mapping in the diagnosis of mild neonatal hyperbilirubinemia with 3.0T MRI. Methods From July 2018 to January 2019, 13 neonates with mild hyperbilirubinemia in the Department of Radiology of People′s Hospital of Longhua District in Shenzhen City were selected as the hyperbilirubinemia group and 17 normal neonates in the same period were selected as the normal group. T1WI and T1 mapping were performed on both neonates in the hyperbilirubinemia group and the normal group by Philips 3.0T MRI. T1 signal intensity of the bilateral globus pallidus was measured at the post-processing workstation and the mean value was calculated. T1 mapping was obtained by automatic operation using IR-TSE sequences with 8 different inversion times. T1 value of the bilateral globus pallidus were measured and the average was calculated. The difference of T1 signal intensity and T1 value between the two groups were compared, and the correlation between T1 signal intensity and T1 value of the globus pallidus with peak value of total bilirubin were analyzed separately. Results The peak value of serum bilirubin in the hyperbilirubinemia group was higher than that in the normal group, and the difference was statistically significant (P＜0.05). The T1 signal intensity in the hyperbilirubinemia group was higher than that in the normal group, and the difference was statistically significant (P＜0.05). T1 value of globus pallidum in the hyperbilirubinemia group was lower than that in the normal group, and the difference was statistically significant (P＜0.05). The T1 signal intensity of globus pallidum was positively correlated with the peak value of total bilirubin (r=0.675, P=0.000). T1 value of globus pallidum was slightly negatively correlated with the peak value of serum total bilirubin (r=-0.455, P=0.012).Conclusion The T1 signal intensity and T1 value of globus pallidus in patients with mild neonatal hyperbilirubinemia are different from those in normal neonates, and have implications for the diagnosis of early acute bilirubin encephalopathy.

Key words： Neonatal jaundice T1 signal intensity T1 value T1 mapping

作者简介: 丁玲（1985-），女，硕士，主治医师，研究方向：神经影像学

引用本文:

丁玲; 杜江齐; 曾剑兵; 王新正. 3.0T磁共振T1WI与T1 mapping在轻度新生儿高胆红素血症诊断中的临床价值[J]. 中国当代医药, 2020, 27(16): 175-177.
DING Ling; DU Jiang-qi; ZENG Jian-bing; WANG Xin-zheng. Clinical value of T1WI and T1 mapping in the diagnosis of mild neonatal hyperbilirubinemia with 3.0T MRI. 中国当代医药, 2020, 27(16): 175-177.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I16/175

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