Abstract：Objective To investigate the clinical effect of Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine in the treatment of Sjogren syndrome.Methods From January 2016 to December 2017,60 patients with Sjogren syndrome admitted to the First People′s Hospital of Jiujiang City in Jiangxi Province were selected as subjects.Patients were divided into control group(30 cases)and treatment group(30 cases)according to random number table method.The control group was treated with Methotrexate combined with Hydroxychloroquine.The treatment group was treated with Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine.The total effective rate was compared between the two groups after 8 weeks of treatment.The results of eye Schimer test,dry mouth symptom score,dry eyes symptom score,serum C-reactive protein (CRP)level and erythrocyte sedimentation rate (ESR)at 4 and 8 weeks of treatment were compared between the two groups.Results The total effective rate of treatment in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The results of the Schimer test at 8 weeks of treatment were significantly higher than that at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The results of the Schimer test in the treatment group at 4 and 8 weeks of treatment were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).The scores of dry eyes and dry mouth at 8 weeks of treatment were significantly lower than those at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The scores of dry eyes and dry mouth in the treatment group at 4 and 8 weeks of treatment were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The CRP and ESR levels at 8 weeks of treatment in both groups were significantly lower than that at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The CRP and ESR levels in the treatment group at 4 and 8 weeks of treatment were significantly lower than those in the control group,with statistically significant differences (P＜0.05).Conclusion Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine in the treatment of Sjogren syndrome,the clinical efficacy is better than Methotrexate combined with Hydroxychloroquine treatment.
黄浔芳;李学勇;刘炬. 一贯煎加减联合甲氨蝶呤、羟氯喹治疗干燥综合征的临床效果[J]. 中国当代医药, 2019, 26(3): 99-102.
HUANG Xun-fang LI Xue-yong LIU Ju▲. Clinical effect of Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine in the treatment of Sjogren syndrome. 中国当代医药, 2019, 26(3): 99-102.
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