Abstract：Objective To investigate the application significance of ultrasound in prenatal diagnosis of thalassemia fetus.Methods From January 2016 to January 2018,150 pregnant women whose fetuses were diagnosed as thalassemia in our hospital and 150 normal singleton pregnant women with normal fetuses were selected as observation group and control group respectively.Ultrasound was performed on these pregnant women,the detection of thalassemia by ultrasound was calculated.The blood flow velocity of middle cerebral artery,resistance index,biparietal diameter,cardiothoracic ratio and placental thickness of the two groups were measured and compared.The correlation between ultrasound test indexes and thalassemia was analyzed using multivariate Logistic regression.Results The detection rate of ultrasound for thalassemia was 94.67%.The detection rates of anemia caused by α-thalassemia,β-thalassemia and ABO blood group incompatibility were 96.34%,93.55%and 91.89%,respectively.The blood flow velocity of the middle cerebral artery,biparietal diameter,cardiothoracic ratio and placental thickness in the observation group were higher than those in the control group (P＜0.05),and the resistance index was lower than that in the control group (P＜0.05).After multivariate Logistic regression analysis,the blood flow velocity of the middle cerebral artery,resistance index,biparietal diameter,cardiothoracic ratio,and placental thickness were all closely related to thalassemia.Conclusion The use of ultrasound-related data and indicators for prenatal screening and diagnosis of thalassemia can provide a basis for prenatal diagnosis of thalassemia.
Ngim CF，Lai，NM，Ibrahim H，et al.Counseling for prenatal diagnosis and termination of pregnancy due to thalassemia major：a survey of health care workers′practices in Malaysia[J].Prenat Diagn，2013，33（13）：1226-1232.
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