Abstract：Objective To investigate the effect of Dextrozine combined with Dexmedetomidine in transurethral ureteral lithotripsy. Methods A total of 206 patients who underwent urethral ureteral lithotripsy from August 2017 to July 2018 treated in our hospital were enrolled in the study. They were randomly divided into control group (n=51), group A (n=52), group B (n=51), and group C (n=52). In the control group, Dizocine for anesthesia was used. In the group A, Dizocine combined with 0.17 μg/(kg·h) Dexmedetomidine for anesthesia was used. In the group B, Dizocine combined with 0.33 μg/(kg·h) Dexmedetomidine for anesthesia was used. In the group C, Dextrozine combined with 0.70 μg/(kg·h)Dexmedetomidine for anesthesia was adopted. The hemodynamic indicators and sedation scores were compared among the four groups. The occurrence of adverse reactions during medication in each group was calculated. Results The mean arterial pressure (MAP) and heart rate (HR) of the group C was lower than those of the other three groups during the lithotripsy and lavage, and the sedation score was lower than those in the other three groups, with statistical significances (P＜0.05). The MAP and HR of the group B was lower than those of the control group and group A, and the sedation score was higher than that in the control group and group A (P＜0.05). The total incidence of adverse reactions in the group C was higher than those in the other three groups, with statistical significance (P＜0.05). Conclusion The combined anesthesia with Dextrozine and Dexmedetomidine in transurethral ureteral lithotripsy obtains a great effect,and the sedative effect is better, and adverse reactions are fewer in the use of medium-dose of Dexmedetomidine.
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