米索前列醇联合缩宫素在妊娠晚期的引产效果及不良反应评价

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摘要目的探讨米索前列醇联合缩宫素在妊娠晚期引产中的效果及不良反应。方法选择2014年3月~2016年3月在东莞市石碣医院住院分娩的216名孕妇作为研究对象，随机分为观察组和对照组，每组各108例。观察组采用米索前列醇阴道上药联合缩宫素静滴进行引产，对照组采用单纯静滴缩宫素进行引产。观察对比两组孕妇的引产成功率、引产总有效率、引产时间、剖宫产率、产后出血率、胎儿宫内窘迫率和新生儿窒息率等。结果观察组和对照组引产成功率分别是93.5%和81.5%，总有效率分别是98.1%和85.2%，观察组引产成功率和总有效率均高于对照组，差异均有统计学意义（P=0.014、0.002）；观察组引产时间短于对照组[（12.1±1.9）h vs.（19.0±2.0）h]，差异有统计学意义（P=0.000）；观察组剖宫产率低于对照组（25.9%vs.39.8%），差异有统计学意义（P=0.027）。两组产后出血（5.5%vs.6.5%，P=0.762）、胎儿窘迫（8.3%vs.10.2%，P=0.623）以及新生儿窒息（4.6%vs.3.7%，P= 0.744）比较，差异均无统计学意义。结论小剂量米索前列醇联合缩宫素用于妊娠晚期引产，可增加引产成功率，缩短引产时间，提高阴道分娩率，且不增加母儿不良结局。

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	黄容弟
	梁锦伦

关键词 ：妊娠晚期, 米索前列醇, 缩宫素, 引产

Abstract：Objective To explore the effect of Misoprostol combined with oxytocin on the induction of labor in late pregnancy and adverse reactions.Methods A total of 216 pregnant women who were hospitalized in Shijie Hospital of Dongguan City from March 2014 to March 2016 were selected as research subjects,and they were randomly divided into observation group and control group,with 108 cases in each group.The observation group was given vaginal administration of Misoprostol combined with oxytocin intravenous infusion for induction of labor,and the control group was given intravenous drip of oxytocin alone.The successful rate of induction of labor,total effective rate of induction of labor,time of induction of labor,cesarean section rate,postpartum hemorrhage rate,fetal distress rate and neonatal asphyxia rate were observed and compared between the two groups.Results The successful rate of induction was 93.5%and 81.5%in the observation group and the control group respectively,the total effective rate was 98.1%and 85.2%respectively,and the successful rate and the total effective rate in the observation group was higher than those in the control group respectively,the difference was statistically significant(P=0.014,0.002);the time of induction of labor in the observation group was shorter than that in the control group[(12.1±1.9)h vs.(19.0±2.0)h],and the difference was statistically significant(P=0.000);the rate of cesarean section in the observation group was lower than that in the control group (25.9%vs.39.8%),and the difference was statistially significant(P=0.027).There were no statistically significant differences in terms of postpartum hemorrhage(5.5%vs.6.5%,P=0.762),fetal distress(8.3%vs.10.2%,P=0.623),and neonatal asphyxia(4.6%vs.3.7%,P=0.744)between the two groups.Conclusion Low dose of Misoprostol combined with oxytocin can increase the successful rate of induction of labor,shorten induction time,increase the rate of vaginal delivery and do not increase the adverse outcome of mother and child.

Key words： Late pregnancy Misoprostol Oxytocin Induction of labor

作者简介: 黄容弟（1981-），女，主治医师，硕士，研究方向：妊娠期代谢性疾病

引用本文:

黄容弟；梁锦伦. 米索前列醇联合缩宫素在妊娠晚期的引产效果及不良反应评价[J]. 中国当代医药, 2017, 24(1): 116-118.
HUANG Rong-di；LIANG Jin-lun. Evaluation of the effect of Misoprostol combined with oxytocin on the induction of labor in late pregnancy and adverse reactions. 中国当代医药, 2017, 24(1): 116-118.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I1/116

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