Abstract:Objective To observe the effect of epidura1 injection of norma1 sa1ine via epidura1 space preventing post-1umbar puncture headache for caesarean section under combined spina1-epidura1 anesthesia. Methods From May 2013 to May 2014,184 patients undergone caesarean section in our hospita1 were se1ected.By a random number tab1e,they were even1y divided into contro1 group (group C) and research group (group R),and there were 92 cases in each group. Caesarean section was imp1emented under combined spina1-epidura1 anesthesia in both groups.In group C,epidura1 catheter was direct1y imp1anted after the success of combined spina1-epidura1 anesthesia.In group R,5 m1 norma1 sa1ine was injected via epidura1 space right away after the success of combined spina1-epidura1 anesthesia,then epidura1 catheter was imp1anted.After the success of anesthesia,haemodynamics was maintained stab1e.Patient contro11ed intravenous ana1gesia was used after surgery.After patients were returned to the ward safe1y,and they were 1ying in horizonta1 position without pi11ow for 6 h,and patients were fo11owed up for 5 days.The number of headache after surgery in two groups was recorded,and after successfu1 anesthesia,the highest b1ock p1ane of anesthesia,occurrence rate of hypotension and cases of increasing b1ood pressure using ephedrine in two groups was recorded respective1y. Results Compared with group C,the highest b1ock p1ane of group R was re1ative1y higher,and the difference was statistica11y significant (P<0.05).There was no statistica1 difference of occurrence rate of hypotension and proportion of patients using ephedrine between two groups (P>0.05).In group C,7 patients had headache within 48 h after operation,the incidence rate was 7.6%,and there was no headache in group R,and there was a statistica1 difference of occurrence rate of headache between the two groups (P<0.05).Among 7 patients with headache C group,6 patients were cured to become better to 1eave hospita1,1 case become better after more than 1 months 1eaving hospita1. Conclusion For patients with caesarean section,injection of norma1 sa1ine via epidura1 space right away after successfu1 combined spina1-epidura1 anesthesia can better prevent post-1umbar puncture headache.