Abstract：Objective To explore the detection method of improvement the Cimetidine Capsule dissolution rate.Methods HPLC was used to determine the dissolutionrate of Cimetidine Capsule.The measurement results of improved method were compared with Chinese Pharmacopeia.Results On the concentrationscale from 0.02 to 0.2 mg/ml，the peak area had nice linear relationship with concentration，and r，recovery rate and RSD were respectively 0.9998，99.82% and 0.33% (n=6).Conclusion The improved method has advantages of more accurate，more exact，more scientific and strong specificity.
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