Abstract：Objective To understand the immune response，viral suppression and drug resistance of AIDSpatients in our city after antiviral treatment，so as to improve the therapeutic effect.M ethods 52 cases of AIDS patients in Xuzhou Center for Disease Control Prevention and Xuzhou Infectious Disease Hospital from January 2011 and August 2013 were selected as the research group，antiviral therapy with 2 nucleoside reverse transcriptase inhibitors（NRTI）and 1 non-nucleoside reverse transcriptase inhibitors（NNRTI）was used to 52 patients，CD4+cell count and viral load were observed with 6，12，18，24 months，and the drug resistance was detected by＞1000 copy/ml.Results Before antiviral treatment，the average value of CD4+cells in 52 patients was（181±112）/μl，after 6 months of treatment，the average value of CD4+cellswas（272±106）/μl，which was higher than that before treatment，with significant difference（t=2.013，P＜0.05）.Viral load was in a high level in most patients before treatment，71.15%（37/52）was decreased to a low level after treatment.Drug resistance rate was 12.5%（1/8），33.33%（3/9），35.29%（6/17），and 44.44%（8/18）respectively in the treatment of 6，12，18 and 24months.Themutation sites of nucleoside resistance were relatively concentrated，mainly in the 184V mutation，and highly resistant to lamivudine，zidovudine，stavudine.The mutation sites of non nucleoside resistance were scattered，probably happened in 181C，103N，101E，190A and 108L，and highly resistant to efavirenz and nevirapine.Conclusion Antiviral therapy can effectively control the virus disease，improve the level of cellular immunity，and effectively inhibit the replication of HIV virus. W ith the prolongation of treatment time，drug resistant strains to nucleoside and non-nucleoside drugs are in large numbers.Drug resistancemutation is the result of viral suppression，and the poor compliance is themain reason.
王海舰;张凤池;周长月;刘成勇;张利宁. 艾滋病患者抗病毒治疗耐药性分析及治疗对策的研究[J]. 中国当代医药, 2016, 23(21): 33-36.
WANG Hai-jian;ZHANG Feng-chi;ZHOU Chang-yue;LIU Cheng-yong;ZHANG Li-ning. Analysis of drug resistance of antiviral treatment in patients w ith AIDS and study on treatment strategy. 中国当代医药, 2016, 23(21): 33-36.
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