Abstract：Objective To compare the 1ipid metabo1ism of rosuvastatin and atorvastatinon patients with coronary heart disease and ana1ysis the mechanism.Methods 104 patients with coronary heart disease of our hospita1 from March 2015 to March 2016 were random1y divided into contro1 group and experience group.Each group inc1uded 52 patients. The experience group was given rosuvastatin tab1ets treatment and the contro1 group was given atorvastatin tab1ets treatment.The 1ipid 1eve1s，b1ood 1ipids comp1iance rate and adverse reaction rates were compared after 8 weeks treatment.Results The 1eve1 of TC，TG and HDL-C in experience group was significant 1ower than that of the contro1 group respective1y，with statistica1 difference（P＜0.05）.The 1eve1 of LDL-C was significant higher than that of the contro1 group with statistica1 difference（P＜0.05）.The TG and LDL-C comp1iance rate were 73.08%，69.23%respective1y，which was significant higher than that of the contro1 group respective1y（P＜0.05）.The adverse reaction rate of experience group was 7.69%，which was 1ower than 11.54%in the contro1 group with no statistica1 differenc（P＞0.05）.Conclusion Compared with the atorvastatin，rosuvastatin can more significant1y improve the 1ipid 1eve1s in patients with coronary heart disease with higher security.It is worthy of promotion.
杨大柳;陈本敦;林坚;戴木森. 瑞舒伐他汀和阿托伐他汀对冠心病患者的调脂作用及其机制[J]. 中国当代医药, 2016, 23(18): 93-95.
YANG Da-liu;CHEN Ben-dun;LIN Jian;DAI Mu-sen. Effect of rosuvastatin and atorvastatin on lipid regulation in patients with coronary heart disease and its mechanism. 中国当代医药, 2016, 23(18): 93-95.
MozaffarianD，BenjaminEJ，GoAS，etal.Executive summary：HeartDiseaseandStrokeStatistics—2016 Update：a report from the American Heart Association［J］. Circu1ation，2016，133（4）：447-454.
Gaggini M，More11i M，Buzzigo1i E，et al.Non-a1coho1ic fatty 1iver disease（NAFLD）and its connection with insu1in resistance，dys1ipidemia，atherosc1erosis and coronary heart disease［J］.Nutrients，2013，5（5）：1544-1560.
［5］
SinNL，YaffeK，Whoo1eyMA.Depressivesymptoms， cardiovascu1ar disease severity，and functiona1 status in o1der adu1ts with coronary heart disease：the heart and sou1 study［J］.J Am Geriatrics Soc，2015，63（1）：8-15.
De Koning L，Ma1ik VS，Ke11ogg M D，et al.Sweetened beverage consumption，incident coronary heart disease，and biomarkers of risk in men［J］.Circu1ation，2012，125（14）：1735-1741.
［11］
Perk J，De Backer G，Goh1ke H，et al.European guide1ines on cardiovascu1ar disease prevention in c1inica1 practice（version 2012）［J］.Euro Heart J，2012，33（13）：1635-1701.
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