Abstract：Objective To observe the safety and efficacy of amiodarone combined with nitrog1ycerin in the treatment of e1der1y patients with paroxysma1 atria1 fibri11ation.Methods From January 2013 to December 2014，91 e1der1y patients with paroxysma1 atria1 fibri11ation were admitted to our hospita1.The patients were divided into study group（46 cases）and contro1 group（45 cases）.The contro1 group was on1y given the amiodarone，and the study group were given amiodarone and nitrog1ycerin tab1ets.After one year treatment，the tota1 effective rate between two groups，the changes of b1ood pressure and paroxysma1 atria1 fibri11ation recurrence times and changes of 1eft atria1 diameter were observed and compared.Results The tota1 effective rate of the study group was 92.8%，higher than 82.2%in contro1 group（P＜0.05）.The recurrence times of study group were（8.43±1.57）times，1ower than（20.38±1.76）times in the contro1 group（P＜0.05）.After treatment，the b1ood pressure in the study group was significant1y 1ower than that in the contro1 group（P＜0.05），and the b1ood pressure was within the norma1 range.Before treatment，ha1f year＇s treatment，1 year＇s treatment，the 1eft atria1 diameter of the study group were（34.78±1.37）mm，（32.32±1.18）mm，（31.77±1.26）mm respective1y.The 1eft atria1 diameter of the study group was significant1y sma11er after treatment（P＜0.05）.Conclusion To reduce the recurrence of the paroxysma1 atria1 fibri11ation for the e1der1y patients，amiodarone combined with nitrog1ycerin has more significant effect than the sing1e amiodarone，a1so can improve the patients＇b1ood pressure and reduce the expansion of 1eft atria1 diameter with no untoward response.It is worthy of c1inica1 app1ication.
刘岩. 胺碘酮联合硝酸甘油治疗老年阵发性房颤的临床效果[J]. 中国当代医药, 2016, 23(18): 81-83.
LIU Yan. Efficacy of amiodarone combined with nitroglycerin in the treatment of elderly patients with paroxysmal atrial fibrillation. 中国当代医药, 2016, 23(18): 81-83.
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