脂联素基因T45G多态性和2型糖尿病相关性的Meta分析

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摘要目的综合评价脂联素基因2号外显子第45位点基因与2型糖尿病（T2DM）的相关性。方法电子检索2010～2015年中英文文献库关于脂联素基因T45G与T2DM的相关文献，以显性遗传模式、隐性遗传模式、加性遗传模式的三个指标进行综合汇总评价。结果共计纳入6篇文献，中文2篇，英文4篇，其中观察组（T2DM）共计1119例，对照组（非T2DM）共计1043例。在显性遗传模式中，TT基因型与GG+TG基因型患T2DM危险系数等同［1.13（0.94，1.36）］，差异无统计学意义（P＞0.05）；在隐性遗传模式中，GG基因型明显高于TT+TG基因型患T2DM危险系数［0.67（0.45，0.98）］，差异有统计学意义（P＜0.05）；加性遗传模式中，GG基因型高于TT基因型患T2DM危险系数［0.18（0.12，0.25）］，差异有统计学意义（P＜0.05）。结论脂联素基因2号外显子T45G多态性与T2DM具有一定的相关性，在隐性遗传模式和加性遗传模式中，G等位基因存在较高的致病风险。

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	张建丽
	李兴

关键词 ：脂联素, 2型糖尿病, 基因, 多态性, 危险系数

Abstract：Objective To eva1uate the re1ationship of adiponectin gene exon 2 T45G po1ymorphism with type 2 diabetes me11itus（T2DM）.Methods Chinese-Eng1ish document database was searched from 2010 to 2015，and the references of artic1es were a1so retrieved on adiponectin gene T45G associated with T2DM.The three indexes of dominant genetic mode1，recessive genetic mode1 and additive genetic mode1 were used for comprehensive eva1uation summary.Results 6 Documents were inc1uded，Chinese 2 and Eng1ish 4，wherein the observation group（T2DM）sumed to 1119 cases，in the contro1 group（non-T2DM）sumed to 1043 cases.The dominant mode，the risk factor of T2DM between TT genotype and GG+TG genotype was equiva1ent［1.13（0.94，1.36）］，with no statistica1 differenc（P＞0.05）.The recessive mode，the risk factor of T2DM in GG genotype was significant1y higher than that of genotype TT+TG［0.67（0.45，0.98）］，the difference was statistica11y significant（P＜0.05）；The additive genetic mode1，the risk factor of T2DM in GG genotype was significant1y higher than that of TT genotype［0.18（0.12，0.25）］，the difference was statistica11y significant（P＜0.05）.Conclusion Adiponectin gene exon 2 T45G po1ymorphism with T2DM has a certain re1evance.In a recessive genetic mode and additive genetic mode1，G a11e1e exists the higher risk.

Key words： Adiponectin Type 2 diabetes me11itus Gene Po1ymorphism Risk factor

通讯作者: 李兴（1961-），主任医师，硕士生导师，研究方向：糖尿病及其并发症的防治

引用本文:

张建丽;李兴. 脂联素基因T45G多态性和2型糖尿病相关性的Meta分析[J]. 中国当代医药, 2016, 23(18): 8-11.
ZHANG Jian-li;LI Xing. Relevance meta-analysis of adiponectin gene polymorphism T45G with type 2 diabetes mellitus. 中国当代医药, 2016, 23(18): 8-11.

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