Abstract：Objective To explore the relationship between lower extremity vascular disease and serum uric acid level of type 2 diabetic patients.Methods 384 type 2 diabetic patients from July 2013 to July 2014 of our hospital were selected.Patients were divided into experimental group （with lower extremity vascular disease，76 cases）and control group （without lower extremity vascular disease，308 cases）.Patients in control group were given routine oral drug or insulin，and patients in experimental group were given alprostadil injection to improve lower extremity vascular disease on the basis of control group.The difference of blood uric acid level in two groups was compared.The relationship between blood uric acid level and other clinical index was tested by Spearman test.The related factors between blood uric acid level and lower extremity vascular disease of type 2 diabetic patients was analyzed by Logistic regression analysis.Results The blood uric acid level in experimental group was obvious higher than that of control group with statistical difference（P＜0.05）.The Spearman test results showed that blood uric acid level had positive relationship with BMI，SBP，DBP，TC and TG of type 2 diabetic patients，while had negative relationship with HDL-C（P＜0.05）.Logistic regression analysis results showed that blood uric acid，TC，TG and CRP were dependent related with lower extremity vascular disease of type 2 diabetic patients （P＜0.05）.Conclusion Blood uric acid level has close relationship with lower extremity vascular disease of type 2 diabetic patients，which is the risk factor of occur of lower extremity vascular disease.In the treatment of diabetes，the level of blood uric acid should be strictly controlled.
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