Abstract：Objective To explore the sedation effect of Midazolam combined with hypnotherapy under epidural anesthesia in elderly operation.Methods 90 elderly men with inguinal hernia repair under epidural anesthesia in our hospital from January 2012 to December 2014 were randomly divided into three groups（each group was 30 cases）：group 1 was given hypnotherapy for treatment；group 2 was given Midazolam combined with hypnotherapy for treatment，and group 3 was given Midazolam for treatment.The SCL-90 factor scores anxiety，SBP，DBP，HR，SpO2，RR，Narcotrend，recovering time，numbers of adverse effects，intervention numbers during operation，drug treatment cases，and amnesia degree of patients in groups at entering the room，before intervention，after intervention and leaving room were recorded.Results After intervention，the difference of SBP，DBP，HR，SpO2，RR，Narcotrend，SCL-90 factor scores anxiety and amnesia degree of patients in group 2 had statistical significance compared with group 1 and group 3 （P＜0.05）.The difference of recovering time，drug treatment cases，numbers of adverse effects and intervention numbers during operation in group 3 had statistical significance compared with group 1 and group 2 （P＜0.05）.Conclusion Midazolam combined with hypnotherapy under epidural anesthesia in elderly operation with better sedation effects and decreases the risk of respiratory depression and hypotension.
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