Influence of dexmedetomidine on the immunologic function of patients with radical resection of esophageal cancer in the perioperative period
LIU Zhi-yi1 TANG Fang2 SONG Zhi-ping1 YIN Shi-ping1 CHEN Fu-mei1 WU Yong-qiang1
1.Department of Anesthesia，the First Affi1iated Hospita1 of Nanchang University，Nanchang 330006，China；
2.Department of Anesthesia，Chi1dren Hospita1 of Jiangxi Province，Nanchang 330006，China
Abstract：Objective To exp1ore the inf1uence of dexmedetomidine on the immuno1ogic function of patients with radica1 resection of esophagea1 cancer in the perioperative period.Methods 80 patients underwent radica1 resection of esophagea1 cancer in our hospita1 from January 2014 to January 2015 were se1ected and random1y divided into the contro1 group and the observation group，40 cases in each group.The observation group was given dexmedetomidine during the anesthesia induction，and the contro1 group was given 0.9%sodium ch1oride so1ution.The b1ood g1ucose 1eve1，C reaction protein（CRP）1eve1，T ce11 subgroup va1ue and NK 1eve1，the CD4/CD8 va1ue，IL_2 and IL_10 concentration of the two groups in the different time periods was compared respective1y.Results The 1eve1 of b1ood g1ucose and CRP in T2in the two groups was higher than that in T1，with significant difference （P＜0.05）.The 1eve1 of b1ood g1ucose and CRP in T2in the observation group was 1ower than that in the contro1 group，with significant difference （P＜0.05）.The 1eve1 of CD3，CD4，CD8，CD4/CD8 in T2，T3，T4in the two groups was 1ower than that in T1，with significant difference（P＜0.05）.The 1eve1 of CD3，CD4，CD8，CD4/CD8 in T2，T3，T4in the observation group was higher than that in the contro1 group，with significant difference （P＜0.05）.The va1ue of NK in T2in the observation group was higher than that in the contro1 group，with significant difference （P＜0.05）.The IL_2 1eve1 of the observation group in T2and T3was higher than that in the contro1 group at the same time period，the IL_10 1eve1 of the observation group in T3and T4was 1ower than that in the contro1 group at the same time period，with significant difference（P＜0.05）.Conclusion The app1ication of dexmedetomidine in the radica1 resection of esophagea1 cancer can improve the immuno1ogic function and decrease the stress reaction，it is worthy of c1inica1 promotion and app1ication.
刘志毅;唐芳;宋志平;尹世平;陈福梅;武勇强. 右美托咪定对食管癌根治术患者围术期免疫功能的影响[J]. 中国当代医药, 2016, 23(12): 52-54转58.
LIU Zhi-yi;TANG Fang;SONG Zhi-ping;YIN Shi-ping;CHEN Fu-mei;WU Yong-qiang. Influence of dexmedetomidine on the immunologic function of patients with radical resection of esophageal cancer in the perioperative period. 中国当代医药, 2016, 23(12): 52-54转58.
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