Abstract：Objective To explore the curative effect of oral Ibuprofen in different gestational ages (GA)premature infants with patent ductus arteriosus(PDA).Methods The premature infants of gestational age＜37 weeks for 2427 cases were examined by Doppler ultrasound in our hospital from November 2013 to October 2016,and they were divided into ten groups by differentgestationalages:15 cases＜28 weeks,43 cases of28 weeks,81 cases of29 weeks,156 cases of30 weeks, 267 cases of 31 weeks,336 cases of 32 weeks,359 cases of 33 weeks,457 cases of 34 weeks,371 cases of 35 weeks, 342 cases of 36 weeks,and each premature infant with a hemodynamically significant patent ductus arteriosus(hsPDA) was treated by oral Ibuprofen.The course of treatment was 3 days.They were given Ibuprofen 10 mg/kg,then Ibuprofen 5 mg/kg after 24 and 48 hours,and they were examined by Doppler ultrasound when one or two days after the treatment. The rate ofartery catheter closure was counted,and the side effects ofIbuprofen was observed.Results There were 203 infants with hsPDA in 2427 premature infants.The closure rate ofeach group was 63.6%in less than 28 weeks,71.4%in 28 weeks, 74.1%in 29 weeks,77.1%in 30 weeks,80.4%in 31 weeks,82.1%in 32 weeks,89.5%in 33 weeks,92.3%in 34 weeks, 100.0%in 35 weeks,100.0%in 36 weeks.There were 17 cases with adverse reactions,including 4 cases ofgastrointestinal bleeding,7 cases of gastric retention,2 cases of abdominal distension and 4 cases of oliguria.Conclusion In the treatment of PDA premature infants with different gestational age,Ibuprofen has the characteristic of the smaller of the gestational age,the lower closure rate of PDA,and the adverse reactions of Ibuprofen is easy to be observed and treated, it is worthy of clinical application.
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