两种抗凝药物对高危出血倾向行连续血液净化患者的凝血、电解质、血脂和炎症因子影响的比较

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Abstract Objective To compare the influence of Sodium Citrate anticoagulation and Low Molecular Weight Heparin Sodium on blood clotting, electrolyte, blood lipid and inflammation factor in patients with high-risk hemorrhage prone to continuous blood purification (CBP).Methods A total of 125 cases of critically ill patients treated with CBP in our hospital from January 2015 to March 2017 were collected and randomly divided into the observation group(65 cases)and the control group (60 cases) according to the time of admission.The observation group received Sodium Citrate anticoagulation, while the control group received Low Molecular Weight Heparin Sodium anticoagulation.The blood clotting,serum creatinine (SCr), blood urea nitrogen (BUN), electrolyte, blood lipid and inflammation factor were compared between the two groups.Results After treatment, the levels of SCr and BUN of the observation group were obviously lower than those of the control group, the life of filter in the observation group was significantly longer than that in the control group, and the activated partial clotting enzyme (APTT) in the observation group was shorter than that in the control group, there were significant differences (P＜0.05).Conclusion Compared with Low Molecular Weight Heparin Sodium anticoagulation, Sodium Citrate anticoagulation group has little effect on coagulation index in high risk hemorrhage patients, which can reduce the level of SCr and BUN in peripheral blood of patients and prolong the service life of filters.

Key words： Sodium Citrate Low Molecular Weight Heparin Sodium High-risk bleeding Continuous blood purification

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	WAN Wei-wei
	XU Li

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WAN Wei-wei,XU Li. Comparison of the influence of two anticoagulants on blood clotting, electrolyte, blood lipids and inflammatory factors in patients with high-risk hemorrhage prone to continuous blood purification[J]. 中国当代医药, 2019, 26(12): 85-87转91.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I12/85

[5]	郑茹娜.局部枸橼酸抗凝在高危出血患者CBP 治疗中的应用及护理[J].护士进修杂志，2013，28（9）：807-808.
[8]	唐玮，张恬.不同抗凝策略在马蜂蜇伤患者CRRT 治疗中的应用及护理[J].重庆医科大学学报，2017，42（9）：1200-1203.
[1]	Xu J，Cui Y，Tian X.Early continuous veno-venous hemofiltration is effective in decreasing intra-abdominal pressure and serum interleukin-8 level in severe acute pancreatitis patients with abdominal compartment syndrome[J].Blood Purif，2017，44（4）：276-282.
[2]	Li P，Qu LP，Qi D，et al.High-dose versus low-dose haemofiltration for the treatment of critically ill patients with acute kidney injury： an updated systematic review and meta-analysis[J].BMJ Open，2017，7（10）：e014171.
[3]	Schilder L，Nurmohamed SA，ter Wee PM，et al.Coagulation，fibrinolysis and inhibitors in failing filters during continuous venovenous hemofiltration in critically ill patients with acute kidney injury：effect of anticoagulation modalities[J].Blood Purif，2015，39（4）：297-305
[4]	Zhao S，Ou H，Peng Y，et al.Role of local citrate anticoagulation in continuous blood purification to patients at high risk of bleeding in ICU[J].Zhong Nan Da Xue Xue Bao Yi Xue Ban，2016 ，41（12）：1334-1339.
[6]	Wu B，Zhang K，Xu B，et al.Randomized controlled trial to evaluate regional citrate anticoagulation plus low-dose of dalteparin in continuous veno-venous hemofiltration[J].Blood Purif，2015，39（4）：306-312.
[7]	Li L，Lu G.Surveying the status of continuous blood purification technology application in Chinese pediatric intensive care unit[J].Zhonghua Er Ke Za Zhi，2014，52（3）：201-204.
[9]	杨秋平，李国强.血液净化技术在妊娠合并急性中毒患者治疗中的应用效果[J].武警后勤学院学报（医学版），2016，25（7）：548-551.
[10]	燕朋波，李国强.连续性血浆吸附滤过治疗急性药物中毒患者的临床应用及干预策略研究[J].中国血液净化，2016，15（7）：353-357.
[11]	许凤英，李琴.尿激酶联合低分子肝素钠治疗动静脉内瘘栓塞的效果观察及护理[J].现代临床护理，2016，15（6）：40-43.
[12]	Kirwan CJ，Hutchison R，Ghabina S，et al.Imple mentation of a simplified regional citrate anticoagulation protocol for post-dilution continuous hemofiltration using a bicarbonate buffered，calcium containing replacement solution[J].Blood Purif，2016，42（4）：349-355.
[13]	Jacobs R，Honore PM，Hendrickx I，et al.Regional citrate anticoagulation for continuous renal replacement therapy：all citrates are not created equal![J].Blood Purif，2016，42（3）：219-220.
[14]	Zakharchenko M，Leden P，Rulísek J，et al.Ionized magnesium and regional citrate anticoagulation for continuous renal replacement therapy[J].Blood Purif，2016，41（1-3）：41-47.
[15]	Jakob G，Janko K，Miha B，et al.Long-term citrate anticoagulation in chronic hemodialysis patients[J].Ther Apher Dial，2011，15（3）：278-282