甲基强的松龙与硫酸镁治疗重症支气管哮喘的效果

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Abstract Objective To investigate the effects of Methylprednisolone and Magnesium Sulfate in the treatment of severe bronchial asthma.Methods A total of 110 patients with severe bronchial asthma admitted to our hospital from May 2017 to February 2018 were enrolled, they were divided into the observation group (n=55) and the control group(n=55) according to random number table method.The control group was treated with Methylprednisolone on the basis of conventional treatment, and the observation group was treated with Magnesium Sulfate on the basis of the control group.After treatment, the total effective rate of treatment, the incidence of adverse reactions, and the lung function indicators (peak expiratory flow [PEF], total lung volume [FVC], volume of gas exhaled in the first second of maximum expiratory volume [FEV1]) were compared between the two group.Results The total effective rate of treatment in the observation group was 94.55%, which was higher than that in the control group (81.81%), and the difference was statistically significant (P＜0.05).The incidence of adverse reactions in the observation group was 3.64%, which was lower than 16.36% in the control group, and the difference was statistically significant (P＜0.05).The FVC of the observation group was (3.87±0.95) L, which was higher than that of the control group ([2.89±0.87] L), the difference was statistically significant (P＜0.05).The FEV1 of the observation group was (2.50±0.78) L, which was higher than that of the control group ([2.01±0.41] L), the difference was statistically significant (P＜0.05).The PEF of the observation group was (3.41±0.96) L/s, which was higher than that of the control group ([2.73±0.53] L/s), the difference was statistically significant(P＜0.05).Conclusion Methylprednisolone combined with Magnesium Sulfate in the treatment of severe bronchial asthma has better effect, higher safety and better improvement of lung function, which is worthy of clinical promotion.

Key words： Methylprednisolone Magnesium Sulfate Severe bronchial asthma Treatment total efficiency rate

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LI Na. Effect of Methylprednisolone and Magnesium Sulfate in the treatment of severe bronchial asthma[J]. 中国当代医药, 2019, 26(12): 82-84.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I12/82

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