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| Influence of early enteral nutrition on inflammatory status, cellular immune function and nutritional status of acute severe pancreatitis |
| ZHANG Lei |
| EICU, Affiliated Zhongshan Hospital of Dalian University in Liaoning Province, Dalian 116001, China |
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Abstract Objective To investigate the influence of early enteral nutrition on inflammatory status, cellular immune function and nutritional status of acute severe pancreatitis.Methods A total of 80 cases with acute severe pancreatitis admitted in our hospital from October 2015 to November 2017 were selected as research objects and divided into the observation group and the control group according to the random number table method, 40 cases in each group.The observation group was given early enteral nutrition, and the control group was given complete parenteral nutrition.The changes of serum proteins such as transferrin, prealbumin and albumin after intervention were compared between the two groups.The levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) after intervention and the levels of CD4+, CD8+ and CD4+/CD8+ after intervention were counted.Results After intervention, the levels of transferrin, prealbumin and albumin in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P＜0.05).The levels of TNF-α, hs-CRP and IL-6 in the observation group after intervention were significantly higher than those in the control group, and the differences were statistically significant (P＜0.05).The levels of CD4+ and CD8+ in the observation group after intervention were significantly higher than those in the control group, and the differences were statistically significant (P＜0.05).The ratio of CD4+/CD8+ in the observation group after intervention was greater than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion For patients with acute pancreatitis, early enteral nutrition support can improve the nutritional status and reduce inflammation and improve immunity.
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