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| Clinical effect of Amlodipine Atorvastatin Calcium Tablets treating hypertension complicated with coronary heart disease |
| AI Jian-hua |
| Shatu Community Health Service Center in Chengbei Subdistrict of Yushui District,Jiangxi Province,Xinyu 338000, China |
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Abstract ObjectiveTo analyze the clinical effect of Amlodipine Atorvastatin Calcium Tablets treating hypertension complicated with coronary heart disease.Methods108 patients with hypertension complicated with coronary heart disease treated by our hospital from July 2015 to July 2016 were selected as objects,and they were randomly divided into two groups,each group had 54 cases.The control group was given Extended Release Tablets of Nifedipine,while the observation group was given Amlodipine Besylate and Atorvastatin Calcium Tablets,after 2 months,blood lipid indexes, clinical effect 1 and 2 months of treatment,inflammatory indexes and adverse reactions after treatment between two groups were compared.ResultsCompared with the control group,LDL-C,TG,TC value was lower and HDL-C value was higher after treatment in the observation group (P＜0.05).After treatment,the IL-6,vWF,NO,ET index in the observation group compared with the control group was statistically significant(P＜0.05),it had no statistically significant differences in the level of CRP and TNF-α (P＞0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between two groups (P＞0.05).ConclusionAmlodipine Besylate and Atorvastatin Calcium Tablets treating hypertension complicated with coronary heart disease can achieve a relatively significant clinical effect,and it can lower blood lipid,eliminate inflammatory factors with high safety,and it is worthy of further promotion.
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| [1] |
樊彩妮，赵海鹰，蒋玲，等.苯磺酸氨氯地平和氨氯地平阿托伐他汀钙片治疗轻中度原发性高血压合并颈动脉粥样硬化患者的疗效[J].中华高血压杂志，2016，24（7）：674-677.
|
| [2] |
李玉敏.血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗高血压并冠心病的临床疗效及其对血脂、血管内皮功能及炎症的影响[J].实用心脑肺血管病杂志，2016，24（7）：90-93.
|
| [3] |
杨漫沩，何晓玲，刘欣，等.氨氯地平联合阿托伐他汀钙片对高血压合并冠心病的治疗效果[J].贵阳医学院学报，2015，40（2）：201-204.
|
| [4] |
翟玫，郭远林，吴娜琼，等.老年冠心病患者服用他汀类调脂药物单中心横断面分析[J].中华老年心脑血管病杂志，2016，18（3）：237-239.
|
| [5] |
巩煜晓，蒋利利.探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床疗效[J].实用心脑肺血管病杂志，2016，10（4）：223-223.
|
| [6] |
常瑛，文爱东，李昌炜，等.复方苯磺酸氨氯地平/阿托伐他汀钙片的人体药动学[J].中国医院药学杂志，2008，28（19）：1672-1676.
|
| [7] |
蒙钟文.对高血压伴高血脂患者行苯磺酸氨氯地平联用阿托伐他汀钙治疗的效果分析[J].中国医学前沿杂志电子版，2014，6（5）：75-77.
|
| [8] |
陈慧敏，许逸飞.苯磺酸氨氯地平联合阿托伐他汀钙治疗老年高血压伴血脂异常的临床研究[J].中国临床药理学杂志，2016，32（12）：1072-1074.
|
| [9] |
王晓冬，曾波，许春平.氨氯地平联合阿托伐他汀治疗高血压合并冠心病的临床观察[J].广西医科大学学报，2015，32（3）：466-467.
|
| [10] |
刘晓霞.氨氯地平联合阿托伐他汀钙对老年冠心病患者IL-6、IL-4、IL-10及炎性因子影响的研究[J].国际老年医学杂志，2016，37（4）：152-154.
|
| [11] |
任川，祖凌云，郑乐民，等.氨氯地平/阿托伐他汀复方制剂对初发高血压伴边缘血脂异常患者血管内皮功能的影响[J].中国心血管杂志，2014，19（2）：86-90.
|
| [12] |
董素娟，周军，代晓杰.氨氯地平联合阿托伐他汀对老年急性缺血性卒中合并高血压患者的影响[J].川北医学院学报，2016，31（5）：745-748.
|
| [13] |
牛连英，赵晓静，周辰光.缬沙坦联合辛伐他汀治疗高血压伴高血脂的临床观察[J].医学综述，2014，20（11）：2103-2104.
|
| [14] |
徐南飞，陈晓雷，马志伟，等.阿托伐他汀治疗冠心病合并脑梗死的临床研究[J].现代生物医学进展，2014，14（35）：6913-6915.
|
| [15] |
高盼，戈文兰，张根元，等.氨氯地平阿托伐他汀钙片的处方和工艺研究[J].华西药学杂志，2014，29（3）：254-256.
|
|
|
|
