Abstract：Objective To explore clinical effect of Tripterygium Wilfordii Glycosides in the treatment of chronic kidney disease.Methods 50 cases of chronic kidney disease treated in our hospital from July 2014 to January 2017 were selected as the study objects,and were divided into the control group and the study group according to random number table method,25 cases in each group.The control group was given routine Telmisartan treatment,and the study group was given Tripterygium Wilfordii Glycosides treatment on the basis of the control group.24 h urinary protein quantification,serum creatinine(SCr)and urea nitrogen (BUN)and other indicators of renal function changes before and after treatment,clinical effect and adverse reactions were compared in the two groups.Results There were no significant differences in the level of 24 h protein,SCr and BUN between the two groups before treatment(P＞0.05).The indexes level of 24 h protein,SCr and BUN in the two groups after treatment was lower than that before treatment,and the indexes level of 24 h protein,SCr and BUN in the study group after treatment was lower than that in the control group,with significant difference (P＜0.05).The clinical effective rate of the study group was 96.00%,which was higher than that of 68.00%of the control group,with significant difference(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion For chronic kidney disease and proteinuria,tripterygium Wilfordii Glycosides can more effectively reduce proteinuria and delay progression of chronic kidney.
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