A meta-analysis of risk factors for cognitive impairment in hypertensive patients
ZOU Lian-yu1 ZHENG Li-wei1▲ FAN Wei-ying1 CHEN Shun2 LIU Wei-hua3
1.School of Nursing,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350122,China;
2.College of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350122,China;
3.Department of Emergency,Xiamen Branch,Zhongshan Hospital,Fudan University,Fujian Province,Xiamen 361015,China
Abstract:Objective To explore the risk factors of cognitive impairment(CI)in hypertensive patients by meta-analysis.Methods The literatures related to risk factors of CI in hypertensive patients were retrieved from PubMed,Embase,Web of Science,Cochrane Library,China National Knowledge Infrastructure,VIP database,Wanfang database,Chinese Biomedical Literature database(CBM).The retrieval time limit was from the establishment of the database to May 2020.Two researchers independently screened the literatures,extracted the data,evaluated the literature quality and metaanalysis was performed using RevMan 5.3 software.Results A total of 25 studies were included.Meta-analysis results showed that advanced age(OR=1.11,95%CI[1.07,1.16], P<0.000 01),low educational level(OR=4.44,95%CI[2.21,8.93], P<0.0001),high systolic blood pressure(OR=1.37,95%CI[1.18,1.59], P<0.0001),high microalbumin creatinine ratio(OR=1.18,95%CI[1.08,1.28], P=0.0003),hyperhomocysteinemia(OR=1.65,95%CI[1.27,2.14], P=0.0002),history of cerebrovascular disease(OR=2.26,95%CI[1.58,3.24], P<0.000 01)were risk factors for patients with CI in hypertension(P<0.05).High insulin resistance index was not a risk factor for patients with CI in hypertension(OR=1.57,95%CI[0.92,2.67], P=0.10).Conclusion The current evidence shows that old age,low education level,high systolic blood pressure,high microalbumin creatinine ratio,hyperhomocysteinemia and history of cerebrovascular disease are risk factors for CI in hypertensive patients,but the conclusion still needs more high quality research further validation.
邹连玉;郑丽维;范维英;陈舜;刘伟华. 高血压患者认知功能障碍危险因素的meta分析[J]. 中国当代医药, 2021, 28(25): 4-8.
ZOU Lian-yu; ZHENG Li-wei;FAN Wei-ying;CHEN Shun; LIU Wei-hua. A meta-analysis of risk factors for cognitive impairment in hypertensive patients. 中国当代医药, 2021, 28(25): 4-8.
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