Objective To explore the effect of warming carbon dioxide pneumoperitoneum on the changes of body temperature and blood loss in patients undergoing laparoscopic hepatolobectomy.Methods A total of 30 patients with laparoscopic hepatectomy admitted to Jiangxi Provincial People′s Hospital from October 2018 to may 2019 were selected as subjects and divided into experimental group and control group by the random number table method, with 15 cases in each group.Patients in the experimental group were treated with heated carbon dioxide pneumoperitoneum and the control group were treated with normal temperature carbon dioxide pneumoperitoneum.The vital signs and complications of the two groups were compared.Results There was no significant difference in body temperature between the two groups before pneumoperitoneum, three hours after pneumoperitoneum, half an hour after operation and one hour after operation (P＞0.05).The body temperature of the experimental group at half an hour after pneumoperitoneum, one hour after pneumoperitoneum, two hours after pneumoperitoneum, five minutes after deflation and one hour after operation in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The amount of intraoperative bleeding in the experimental group was less than that in the control group,and the difference was statistically significant (P＜0.05).The total incidence of complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The use of warming carbon dioxide pneumoperitoneum for patients undergoing laparoscopic hepatectomy can help patients improve their body temperature, reduce intraoperative bleeding and adverse reactions, and has certain promotion value.