Abstract：Objective To investigate the effect of Carvedilol combined with Trimetazidine on vascular endothelial function, blood nitric oxide and endothelin-1 in patients with heart failure.Methods A total of 52 patients with heart failure who were treated in the Affiliated Central Hospital of Shenyang Medical University from April 2019 to April 2020 were selected as the research objects.By drawing lots,they were divided into control group and study group, with 26 cases in each group.Patients in both groups were given conventional treatment with vasodilators, diuretics and tensin anticoagulants.Patients in the control group were treated with Carvedilol on the basis of conventional treatment, and patients in the study group were treated with Carvedilol combined with Trimetazidine on the basis of conventional treatment.The levels of endothelin-1, blood nitric oxide, left ventricular end-diastolic diameter (LVDD), left atrial diameter(LAD), left ventricular ejection fraction (LVEF) and ventricular septal thickness (IVST) before and after treatment and vascular endothelial function after treatment were compared between the two groups.Results Before treatment, there were no statistically significant differences in the levels of endothelin-1 and nitric oxide between the two groups (P＞0.05).After treatment, the levels of endothelin-1 in the two groups were lower than those before treatment, and the levels of blood nitric oxide were higher than those before treatment, the differences were statistically significant (P＜0.05).After treatment, the level of endothelin-1 in the study group was lower than that in the control group, and the level of blood nitric oxide was higher than that in the control group, the differences were statistically significant (P＜0.05).After treatment, the vasodilator function in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in LVDD, LAD, LVEF and IVST between the two groups (P＞0.05).After treatment, LVDD, LAD and IVST of the two groups were lower than those before treatment, LVEF was higher than before treatment, and the differences were statistically significant (P＜0.05).After treatment, LVDD, LAD and IVST in the study group were lower than those in the control group, LVEF was higher than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion Carvedilol combined with Trimetazidine has an ideal effect in the treatment of heart failure.It can increase blood nitric oxide levels, reduce endothelin-1 levels, improve heart function, and improve vasodilation.It is recommended to be used in clinical practice.
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