Abstract：Objective To explore the effect of heated humidified high flow nasal canula ventilation (HHHFNC) on preventing neonatal extubation failure.Methods From June 2016 to June 2019, a total of 211 children in Neonatal Intensive Care Unit (NICU) of Jiangxi Provincial Children′s Hospital who needed non-invasive assisted ventilation after tracheal intubation were selected as subjects.According to the random number table method, they were divided into nasal continuous positive airway pressure ventilation (NCPAP) group (n=102) and HHHFNC group (n=109).The two groups of children were compared with the average airway pressure (MAP) before extubation, the inhaled oxygen concentration before extubation (FiO2), the application time of the invasive ventilator, total number of oxygen days and other respiratory parameters, the failure of extubation and the occurrence of complications.Results There were no significant differences between the two groups of children before extubation MAP and invasive ventilator application time, FiO2 concentration before extubation and other respiratory parameters, the differences were not statistically significant (P＞0.05).Total number of oxygen days of HHHFNC group was shorter than that in NCPAP group, the difference was statistical significance (P＜0.05).There was no significant difference in the extubation failure rate between the two groups (P＞0.05).The incidence of adverse events (nosocomial infection, chronic lung disease) and complications (abdominal distension,nasal injury) of children in the HHHFNC group were lower than those in the NCPAP group, the differences were statistically significant (P＜0.05).Conclusion Compared with the NCPAP method, the application of HHHFNC can effectively shorten the total number of days of oxygen use in children and reduce complications and adverse reactions, and is more meaningful in preventing neonatal extubation failure.
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