Effect comparison of Oxaliplatin combined with Capecitabine and Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium in the treatment of advanced colorectal cancer
WU Yu-ling
Department of Oncology,the Third People′s Hospital of Jingdezhen City,Jiangxi Province,Jingdezhen 333000,China
Abstract:Objective To compare the effect of Oxaliplatin combined with Capecitabine and Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium in the treatment of advanced colorectal cancer.Methods A total of 66 patients with advanced colorectal cancer admitted to the Third People′s Hospital of Jingdezhen City from August 2016 to August 2017 were selected as the research subjects.According to the random number table method,they were divided into the Capecitabine group (n=33) and the Tegafur Gimeracil Oteracil Potassium group (n=33).In the Capecitabine group,Oxaliplatin combined with Capecitabine was used,and in the Tegafur Gimeracil Oteracil Potassium group,Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium was used for treatment.The clinical efficacy,adverse reactions and median time to disease progression (TTP) were compared between the two groups after 2 courses of treatment.Results There was no statistically significant difference in the total effectiveness rate between the two groups (P>0.05).The incidence of nausea and vomiting and hand-foot syndrome in the Tegafur Gimeracil Oteracil Potassium group were higher than those in the Capecitabine group,and the differences were statistically significant (P<0.05).There was no significant difference in the median TTP between the two groups (P>0.05).Conclusion In patients with colorectal cancer,Oxaliplatin combined with Capecitabine or Tegafur Gimeracil Oteracil Potassium can obtain similar effects,but Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium can reduce the occurrence of nausea and vomiting and hand-foot syndrome.
吴玉玲. 奥沙利铂联合卡培他滨与奥沙利铂联合替吉奥治疗晚期结直肠癌的效果对比[J]. 中国当代医药, 2021, 28(5): 93-95.
WU Yu-ling. Effect comparison of Oxaliplatin combined with Capecitabine and Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium in the treatment of advanced colorectal cancer. 中国当代医药, 2021, 28(5): 93-95.