Abstract：Objective To compare the effect of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve (DOR).Methods The clinical data of 272 cases of DOR patients under 35 years of age who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from January 2016 to June 2017 in our hospital were retrospectively analyzed.According to the different ovulation induction regimens, the patients were divided into group A (112 cases) and group B (160 cases).The patients in the group A received early follicular long-term regimen, and the patients in the group B received antagonist regimen.The ovulation induction effect and pregnancy outcomes were compared between the two groups.The ovulation induction indicators included gonadotrophin (Gn) total use, luteinizing hormone (LH) in human chorionic gonadotropin (HCG) day,HCG endometrial thickness, number of eggs obtained, high quality embryo rate and number of transplanted embryos.The clinical pregnancy rate, implantation rate, and live birth rate were used as the evaluation criteria for pregnancy outcome.Results The total use of Gn in group A was more than that in group B, the level of LH in HCG day was lower than that in group B, the HCG endometrial thickness, number of eggs obtained, planting rate, clinical pregnancy rate and live birth rate were higher than those in group B, and the differences were statistically significant (P<0.05).There were no significant differences in the quality of embryo rate and the number of transplanted embryos between the two groups (P>0.05).Conclusion For young patients with DOR, the effect of the early follicular long-term regimen is superior to that of the antagonist regimen and it is more suitable as an alternative regimen for ovarian hyper-stimulation.
郭岩文；郑 娟；蔡嘉力；刘兰兰；任建枝. 早卵泡期长方案与拮抗剂方案治疗卵巢储备功能下降年轻患者的效果比较[J]. 中国当代医药, 2019, 26(15): 62-64.
GUO Yan-wen； ZHENG Juan； CAI Jia-li ；LIU Lan-lan； REN Jian-zhi. Effect comparison of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve. 中国当代医药, 2019, 26(15): 62-64.
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