巧囊或其他原因所致的卵巢储备功能下降患者IVF/ICSI助孕结局的比较

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摘要目的比较巧囊（子宫内膜异位囊肿）所致的卵巢储备功能下降与其他原因所致的卵巢储备功能下降患者的体外受精（IVF）/卵胞浆内单精子注射（ICSI）助孕结局。方法选取2014年10月～2015年7月于本中心198例IVF/ICSI助孕年龄＜40岁的卵巢储备功能下降的患者（共计311个周期），按是否合并巧囊（术后或未手术）分为两组。A组：合并巧囊的卵巢储备功能下降患者；B组：非合并巧囊的卵巢储备功能下降患者。采用回顾性病例对照分析，分别比较两组患者的基本情况、控制性超促排卵相关数据、实验室相关数据及妊娠结局。结果两组患者在辅助生殖技术（ART）方案、超促排卵方案、Gn起始量、Gn总量、获卵数、2PN数、优势胚胎数、移植胚胎数、移植率、妊娠率、流产率、异位妊娠率、单胎妊娠率及多胎妊娠率比较，差异均无统计学意义（P＞0.05）。巧囊所致卵巢储备功能下降患者的平均年龄显著低于非巧囊组[（33.67±0.34）岁vs（35.04±0.19）岁，P＜0.01]；基础促卵泡生成激素（FSH）显著低于非巧囊组[（9.85±0.46）mIU/m1 vs（11.79±0.34）mIU/m1，P＜0.01]，但是巧囊所致的卵巢储备功能下降的患者，其好胚率显著低于非巧囊组（13.76% vs 25.42%，P＜0.01）。结论巧囊所致的卵巢储备功能下降与非巧囊所致的卵巢储备功能下降相比，其优质胚胎率显著下降，可见巧囊在导致卵巢储备功能下降的同时还会使得卵子质量下降。

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	李晓霞
	吴慧慧
	孙秀静
	王娜

关键词 ：巧囊, 卵巢储备功能下降, 妊娠率

Abstract：Objective To compare IVF/ICSI promoting gestation outcomes of patients with ovarian reserve function dec1ine that resu1t from artfu1 bursa (ovarian endometria1 cyst) or from other reasons. Methods 198 ovarian reserve function dec1ine patients from October 2014 to Ju1y 2015 in our center whose IVF/ICSI promoting gestation age were 1ess than 40 years were se1ected from our center (a tota1 of 311 cyc1es).Patients were divided into two groups according to whether combined with artfu1 bursa (postoperative or not operation) or not: group A，ovarian reserve function dec1ine patients combined with artfu1 bursa；group B，varian reserve function dec1ine patients did not combine with artfu1 bursa.The basica1 situation，contro1 over stimu1ate ovu1ation re1ated data，1aboratory re1ated data and gestation outcomes of two groups were compared by using retrospective case-contro1 ana1ysis. Results There were no statistica1 significance between two groups in ART project，over stimu1ate ovu1ation project，Gn initia1 amount，Gn tota1 amount，get ovum number，2PN number，advantages embryo number，number of transferred embryos，transp1antation rate，pregnancy rate，abortion rate，ectopic pregnancy rate，sing1e pregnancy rate and mu1tip1e pregnancy rate (P＞0.05).A1though the average age of ovarian reserve function dec1ine patients that resu1t from artfu1 bursa was obvious 1ower than non artfu1 bursa group [(33.67± 0.34) years vs (35.04±0.19) years，P＜0.01] and basica1 FSH was obvious 1ower than non artfu1 bursa group [(9.85±0.46) mIU/m1 vs (11.79±0.34) mIU/m1，P＜0.01]，the good embryo rate was obvious 1ower than non artfu1 bursa group (13.76% vs 25.42%，P＜0.01). Conclusion Comparing the ovarian reserve function dec1ine between resu1t from artfu1 bursa and non artfu1 bursa，the good embryo rate has decreased obvious1y.So，we can pre1iminari1y conc1ud that artfu1 bursa a1so make the egg qua1ity dec1ine at the same at 1eading to decrease ovarian reserve function.

Key words： Artfu1 bursa Ovarian reserve function dec1ine Pregnancy rate

引用本文:

李晓霞;吴慧慧;孙秀静;王娜. 巧囊或其他原因所致的卵巢储备功能下降患者IVF/ICSI助孕结局的比较[J]. 中国当代医药, 2016, 23(6): 32-36.
LI Xiao-xia;WU Hui-hui;SUN Xiu-jing;WANG Na. ComParison on IVF/ICSI Promoting gestation outcomes of Patients with ovarian reserve function decline that result from artful bursa or from other reasons. 中国当代医药, 2016, 23(6): 32-36.

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