Abstract:Objective To explore the application of Dexmedetomidine Injection nasal drops in the examination of painless fiberoptic bronchoscopy.Methods Eighty patients who underwent elective painless fiberoptic bronchoscopy in our hospital from January to May 2017 were enrolled in the study,whose ages were 18 to 75 years old,with ASA Ⅰ~Ⅲ.They were randomly divided into Dexmedetomidine nasal drops group (group D) and saline control group (group C), 40 cases in each group.The mean arterial pressure (MAP) and heart rate (HR) in the two groups of patients after 10 minutes of rest (T0), fiberoptic bronchoscopy after passing the glottis and before reaching the bulge (T1) and at the end of the examination (T2) were recorded.The cough and body motion visual analogue scale (VAS) comprehensive score, incidence of adverse events (hypotension, hypertension, bradycardia and tachycardia), total use of Propofol, wake time, and Ricker sedation-incitement (SAS) score were compared between the two groups.Results There were no significant differences in the MAP and HR between the two groups at T0 (P>0.05).The MAP of T1 in both groups was higher than that of T0,and the difference was statistically significant (P<0.05).The HR of T1 in group C was significantly higher than that of T0, and the difference was statistically significant (P<0.05).The HR of T1 in group D was lower than that in group C,and the difference was statistically significant (P<0.05).There were no significant differences in MAP and HR between the two groups at T2 (P>0.05).The comprehensive score of cough and body motion VAS in group D was (4.2±1.6)points, the rate of tachycardia was 12.5%, which was significantly lower than those of group C for (5.6±1.8) points and 22.5% respectively, and the differences were statistically significant (P<0.05).There were no significant differences in the incidence rates of hypotension, hypertension, and bradycardia between the two groups (P>0.05).The total amount of Propofol used in group D was (125.1±40.6) mg, which was significantly less than that in group C for (138.2±31.5) mg,the SAS score of recovery room in group D was (3.9±0.5) points, which was significantly lower than that in group C for(4.8±0.6) points, and the differences were statistically significant (P<0.05).The wake time of patients in group D was(15.2±3.9) min, compared with (15.8±4.2) min in group C, and the difference was not statistically significant (P>0.05).Conclusion Dexmedetomidine Injection nasal drops can be safely and effectively applied to in the examination of general anesthesia painless fiberoptic bronchoscopy, compared with traditional methods, the inspection process and recovery process are more stable, and the amount of Propofol is less, which does not affect the wake time.
晋兆琴;黄辉. 右美托咪定注射液滴鼻在无痛纤维支气管镜检查中的应用研究[J]. 中国当代医药, 2019, 26(12): 105-108.
JIN Zhao-qin;HUANG Hui. Study on the application of Dexmedetomidine Injection nasal drops in the examination of painless fiberoptic bronchoscopy. 中国当代医药, 2019, 26(12): 105-108.
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