粉尘螨滴剂联合枸地氯雷他定治疗粉尘螨过敏慢性荨麻疹的效果

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摘要目的观察粉尘螨滴剂联合枸地氯雷他定治疗粉尘螨过敏慢性荨麻疹的效果。方法选取2015年1月～2016年6月我科门诊诊治的120例慢性荨麻疹患者作为研究对象，采用随机数字表法将其分为试验组（60例）和对照组（60例）。试验组患者舌下含服粉尘螨滴剂，疗程1年，同时口服枸地氯雷他定片8.8 mg，1次/d，疗程4周，4周后根据患者荨麻疹症状控制情况减量维持或停药。对照组患者仅口服枸地氯雷他定片8.8 mg，方法及疗程同试验组。在治疗4周、3个月、半年、9个月、1年后进行随访，比较两组患者的治疗总有效率、整体满意度及不良反应发生率。结果试验组患者治疗3、6、9个月及1年后的总有效率均高于治疗4周后，差异有统计学意义（P<0.05）；对照组患者治疗3、6个月后的总有效率与治疗4周后比较，差异无统计学意义（P>0.05），治疗9个月及1年后的总有效率均高于治疗4周后，差异有统计学意义（P<0.05）；两组患者治疗4周后的总有效率比较，差异无统计学意义（P>0.05）；试验组患者治疗3、6、9个月及1年后的总有效率均高于对照组，差异有统计学意义（P<0.05）。1年观察期结束后，试验组患者的整体满意度明显高于对照组，差异有统计学意义（P<0.05）。两组患者的不良反应均比较轻，未影响继续治疗。结论舌下含服粉尘螨滴剂联合枸地氯雷他定治疗粉尘螨阳性慢性荨麻疹，疗效肯定，应用方便和安全。

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	杨榕青
	杨池梅
	黄捷

关键词 ：枸地氯雷他定, 粉尘螨滴剂, 慢性荨麻疹, 特异性免疫治疗

Abstract：Objective To observe the effect of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of chronic urticaria induced by dust mite allergy.Methods Altogether120 patients with chronic urticaria who were treated in the outpatient of our hospital from January 2015 to June 2016 were selected as objects.They were divided into the experimental group (60 cases)and the control group (60 cases)according to the random number table method.The experimental group was sublingually administered with Dust Mite Drops for 1 year,and they were orally given Desloratadine Citrate Disodium Tablets of 8.8 mg at the same time,once a day,for 4 weeks.After 4 weeks,the doses were reduced or stopped according to the control of urticaria symptoms.The control group was only orally given 8.8 mg of Desloratadine Citrate Disodium Tablets,whose method and course of treatment were the same as the experimental group.Follow-up visits were conducted 4 weeks,3,6,9 months,and 1 year after treatment.The total effective rate,overall satisfaction,and incidence of adverse reactions were compared between two groups.Results The total effective rate in the experimental group after 3,6,9 months and 1 year of treatment was higher than that after 4 weeks of treatment,and the differences were statistically significant(P<0.05).The total effective rate of the control group after 3 months and 6 months of treatment was not significantly different from that after 4 weeks of treatment(P>0.05).The total effective rate after 9 months and 1 year of treatment in the control group were higher than those after 4 weeks of treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the total effective rate between two groups after 4 weeks of treatment(P>0.05).The total effective rate after 3,6,9 months and 1 year of treatment in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).At the end of the one-year observation period,the overall satisfaction in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The adverse reactions in both groups were relatively mild and did not affect continuing treatment.Conclusion Sublingual administration of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of dust mite-positive chronic urticaria is effective,convenient and safe.

Key words： Desloratadine citrate disodium Dust mite drops Chronic urticaria Specific immunotherapy

引用本文:

杨榕青;杨池梅;黄捷. 粉尘螨滴剂联合枸地氯雷他定治疗粉尘螨过敏慢性荨麻疹的效果[J]. 中国当代医药, 2018, 25(26): 144-146转151.
YANG Rong-qing;YANG Chi-mei;HUANG Jie. Effect of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of chronic urticaria induced by dust mite allergy. 中国当代医药, 2018, 25(26): 144-146转151.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I26/144

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