阿托伐他汀钙片配合负压密闭钻孔引流治疗慢性硬膜下血肿的效果分析

摘要
图/表
参考文献(19)
相关文章 (7)

全文: PDF (0 KB) HTML (32 KB)
输出: BibTeX | EndNote (RIS)

摘要目的分析阿托伐他汀钙片配合负压密闭钻孔引流与传统钻孔引流治疗慢性硬膜下血肿（CSDH）的疗效。方法纳入2011年1月～2014年1月因CSDH在福建省立医院神经外科手术治疗患者40例，根据手术方案的不同将其分为研究组与对照组。研究组进行负压密闭钻孔引流，术后规律服用阿托伐他汀钙片治疗；对照组进行传统钻孔引流术。观察两组患者手术前后头痛VAS评分、术前血肿量、术后血肿量和术后颅内积气量。结果治疗前，两组患者头痛VAS评分、硬膜下血肿量比较差异无统计学意义（P＞0.05）。研究组术后血肿量为（8.45±6.11）m1、颅内积气（2±1.15）m1，VAS评分（1±0.55）分；对照组术后血肿量为（19.55±7.90）m1、颅内积气（12.05±8.15）m1、VAS评分（3±0.65）分，两组比较差异有统计学意义（P＜0.05）。结论负压密闭钻孔引流配合口服阿托伐他汀钙片能有效缓解患者头痛症状，降低气颅发生率，可作为临床治疗CSDH的治疗方式。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	卢峰
	林世水
	魏德

关键词 ：负压密闭钻孔, 阿托伐他汀钙片, 传统钻孔引流, 颅内积气, VAS评分

Abstract：Objective To ana1yze the efficacy of airtight dri11ing drainage with negative pressure combined with atorvastatin ca1cium tab1ets in the treatment of chronic subdura1 hematoma. Methods 40 patients with CSDH who were operated in neurosurgica1 department of Fujian provincia1 hospita1 from January 2011 to Apri1 2014 were se1ected and divided into research group and contro1 group based on different procedures.Research group was given the vacuum sea1ed drainage,postoperative treatment of regu1ar use of atorvastatin ca1cium tab1ets,whi1e contro1 group was given traditiona1 dri11ing drainage.Preoperative and postoperative VAS scores,hematoma vo1ume,pneumocepha1us were observed. Results Before treatment,there was no significant difference between hematoma or VAS rating in both groups (P＞0.05).For research group,postoperative VAS score was(1±0.55),the residue amount was(8.45±6.11) m1，phemocepha1us was(2±1.15) m1; For contro1 group,VAS score was(3±0.65),the residue amount was(19.55±7.90) m1，phemocepha1us was(12.05±8.15) m1, with statistica1 difference (P＜0.05).The difference was significant (P＜0.05). Conclusion Vacuum sea1ed trepanation and drainage combined with ora1 atorvastatin of atorvastatin can effective1y a11eviate the symptoms of headache and reduce the incidence of pneumocepha1us can be as a treatment moda1ity for c1inica1 treatment of CSDH.

Key words： Airtight dri11ing drainage with negative pressure Atorvastatin ca1cium tab1ets Traditiona1 dri11ing and drainage Phemocepha1us VAS score

基金资助:福建省卫生计生委青年科研课题（2014-1-2）

引用本文:

卢峰；　　林世水；　　魏德. 阿托伐他汀钙片配合负压密闭钻孔引流治疗慢性硬膜下血肿的效果分析[J]. 中国当代医药, 2016, 23(9): 51-53.
LU Feng； LIN Shi-shui ；WEI De. Effect analysis of airtight drilling drainage with negative Pressure combined with atorvastatin calcium tablets in the treatment of chronic subdural hematoma. 中国当代医药, 2016, 23(9): 51-53.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2016/V23/I9/51

[1]	Emich S，Rich1ing B，McCoy MR，et al.The efficacy of dexamethasone on reduction in the reoperation rate of chronic subdura1 hematoma——the DRESH　study：straightforward study protoco1 for a randomized contro11ed tria1[J].Tria1s，2014，15：6.
[2]	Lee KS，Bae WK，Doh JW，et al.Origin of chronic subdura1 haematoma and re1ation to traumatic subdura1 1esions[J]. Brain Inj，1998，12（11）：901-910.
[3]	de Araújo Si1va DO，Matis GK，Costa LF，et al.Chronic subdura1 hematomas and the e1der1y：surgica1 resu1ts from a series of 125 cases：O1d"horses" are not to be shot[J]. Surg Neuro1 Int，2012，3：150.
[4]	王忠诚.神经外科学[M].武汉：湖北科学技术出版社，2005，442-444.
[5]	袁盾，赵杰，刘劲芳，等.417例慢性硬膜下血肿患者的临床特点分析[J].中南大学学报（医学版），2013，38（5）：517-520.
[6]	杨承勇，熊云彪，杨恒，等.内镜辅助下钻孔引流治疗慢性硬膜下血肿[J].中华创伤杂志，2013，29（8）：743-745.
[7]	王慧晓，沈益金，陆洲，等.神经内镜手术治疗慢性硬膜下血肿[J].中华神经外科杂志，2013，29（7）：684-686.
[8]	姚庆宁，肖奎，唐协林，等.临床路径在慢性硬膜下血肿患者的效果分析[J].医学与哲学，2012，33（16）：68-70.
[9]	牙昌权.慢性硬膜下血肿颅骨钻孔血肿引流术后并发症防治探讨[J].河北医学，2014，20（1）：77-79.
[10]	Hohenstein A，Erber R，Schi11ing L，et al.Increased mRNA expression of VEGF within the hematoma and imba1-ance of angiopoietin -1 and -2 mRNA within the neomembranes of chronic subdura1 hematoma[J].J Neurotrauma，2005，22（5）：518-528.
[11]	Stanisic M，Lund-Johansen M，Mahesparan R.Treatment of chronic subdura1 hem atoma by burr-ho1e craniostomy in adu1ts in f1uence of some factors on postoperative recurrence[J].Acta Neurochir（Wien），2005，147（12）：1249-1256.
[12]	Sun TF，Boet R，Poon WS.Non-surgica1 primary treatment of chronic subdura1 haematoma：pre1iminary resu1ts of using dexamethasone[J].Br J Neurosurg，2005，19（4）：327-333.
[13]	De1gado-López PD，Martín-Ve1asco V，Casti11a-Díez JM，et al.Dexamethasone treatment in chronic subdura1 haematoma[J].Neurocirugia（Astur），2009，20（4）：346 -359.
[14]	Dran G，Berthier F，Fontaine D，et al.Effectiveness of adjuvant corticosteroid therapy for chronic subdura1 hematoma：a retrospective study of 198 cases [J].Neurochirurgie，2007，53（6）：477-482.
[15]	Berghauser Pont LM，Dirven CM，Dippe1 DW，et al.The ro1e of corticosteroids in the management of chronic subdura1 hematoma：a systematic review[J].Eur J Neuro1，2012，19（11）：1397-1403.
[16]	Weige1 R，Hohenstein A，Sch1ickum L，et al.Angiotensin converting enzyme inhibition for arteria1 hypertension reduces the risk of recurrence in patients with chronic subdura1 hematoma possib1y by an antiangiogenic mechanism[J].Neurosurgery，2007，61（4）：788-792.
[17]	Araújo FA，Rocha MA，Mendes JB，et al.Atorvastatin inhibits inf1ammatory angiogenesis in mice through down regu1ation of VEGF，TNF -a1pha and TGF -beta1 [J]. Biomed Pharmacother，2010，64（1）：29-34.
[18]	Buttmann M，Lorenz A，Weishaupt A，et al.Atorvastatin partia11y prevents an inf1ammatory barrier breakdown of cu1tured human brain endothe1ia1 ce11s at a pharmaco1ogica11y re1evant concentration[J].J Neurochem，2007，102（4）：1001-1008.
[19]	Wang D，Li T，Tian Y，et al.Effects of atorvastatin on chronic subdura1 hematoma：a pre1iminary report from three medica1 centers[J].J Neuro1 Sci，2014，336（1-2）：237-242.