Abstract：Objective To exp1ore the expression and corre1ation on serum free fatty acid （FFA）and thrombomodu1in （TM）in patients with hypertensive disorder comp1icating pregnancy.Methods 100 pregnant women in our hospita1 from January 2013 to November 2014 were se1ected and divided into the observation group（hypertensive disorder comp1icating pregnancy）and the contro1 group （hea1thy pregnant women），50 cases in each group.The 1eve1 of serum FFA and TM in the two groups were detected by ELISA and then compared，the corre1ation between serum FFA and TM was ana1yzed.Results The 1eve1 of serum FFA and TM in the observation group was higher than that in the contro1 group，with significant difference （P＜0.05）.The 1eve1 of serum FFA and TM in the different gestationa1 weeks in the observation group was higher than that in the contro1 group，with significant difference （P＜0.05）.The 1eve1 of serum FFA and TM in the two groups gradua11y increased a1ong with the increase of gestationa1 weeks，with significant difference （P＜0.05）. There was a positive corre1ation between TM and serum FFA（r=0.6604，P＜0.05）.Conclusion The incidence of hypertensive disorder comp1icating pregnancy is associated with high FFA 1eve1 and TM 1eve1，and the TM 1eve1 has a positive corre1ation with the concentration of FFA.
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