Abstract:ObjectiveTo investigate the application effect of Dexmedetomidine in general anesthesia of orthopedic joint replacement.Methods74 patients undergoing orthopedic joint replacement who were admitted to our hospital from April 1,2016 to March 31,2017 were selected and randomly divided into the observation group and the control group,with 37 cases in each group.The observation group was given Dexmedetomidine intravenous infusion,and the control group was given intravenous infusion of equal volume of normal saline.The MMSE score,S100β level,hemodynamics and adverse events were compared between the two groups of patients undergoing orthopedic joint replacement.ResultsThere was significant difference in the MMSE score and S100β level between the observation group at 3 days and 1 week after treatment and those in the control group (P<0.05).The levels of HR at T3,T4,T5and CVP and MAP at T5in the observation group in the patients undergoing orthopedic joint replacement were significantly lower than those in the control group (P<0.05).The incidence rate of adverse reactions in the patients undergoing orthopedic joint replacement in the observation group was lower than that in the control group(P<0.05).ConclusionThe application of Dexmedetomidine in general anesthesia of orthopedic joint replacement can improve the cognitive function and hemodynamic indices of patients,reduce the incidence of adverse reactions,and the antihypertensive effect is significant.
陈一犀. 右美托咪定在骨科关节置换术全身麻醉中的应用效果[J]. 中国当代医药, 2017, 24(35): 119-121.
CHEN Yi-xi. Effect on the application of Dexmedetomidine in general anesthesia of orthopedic joint replacement. 中国当代医药, 2017, 24(35): 119-121.