Abstract：Objective To investigate themerits of contrast-enhanced ultrasound and conventional ultrasound on superficial lymph node biopsy. Methods 48 patientswith superficial lymphadenopathy were enrolled into study from September 2014 to October 2015.Patients were detected by conventional/contrast-enhanced ultrasonography and pathological biopsy.They were divided into contrast-enhanced ultrasound group（n=27）and conventional ultrasound group（n=21）.Biopsy success rate，diagnostic accuracy rate and incidence of complications between two groupswere compared.Results Incidence of complications in contrast-enhanced ultrasound group（0.00%）was significantly lower than that in conventional ultrasound group（14.29%），with statistical difference（P=0.043）.There were on significant differences in biopsy success rate and diagnostic accuracy rate between two groups（P＞0.05）.Conclusion Contrast-enhanced ultrasound can reduce the incidence of complications on superficial lymph node biopsy，but can not improve biopsy success rate，diagnostic accuracy rate.
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