Abstract：Objective To study the influence of Silicone Gel on the expression of vascular endothelial growth factor (VEGF)in scar model on the back of miniature pig and to explore the mechanism of action of medical Silicone Gel. Methods From July to September in 2015,the minipig back scar model was constructed and were randomly divided into the control group and the Silicone Gel group.The Silicone Gel group was given Medical Silicone Gel Spray after operation for 28 days,the control group was not treated.The animals were sacrificed after operation at 56 days,and the scar of pig back was removed.The changes of VEGF was observed by immunohistochemistry.Results Scar hyperplasia in the Silicone Gel group was significantly reduced,compared with the blank control group.The average optical density of VEGF in the Silicone Gel group was 0.034±0.081,which was lower than 0.110±0.014 in the the control group,with significant difference(P＜0.05).Conclusion Silicone Gel may reduce scar hyperplasia by down-regulation of VEGF.
黎丁菱； 高彦晨 ；农晓琳. 硅酮凝胶对小型猪瘢痕模型血管内皮生长因子表达的影响[J]. 中国当代医药, 2017, 24(3): 123-125.
LI Ding-ling；GAO Yan-chen；NONG Xiao-lin. Influence of Silicone Gel on the expression of vascular endothelial growth factor of scar model in minipig. 中国当代医药, 2017, 24(3): 123-125.
Gauglitz GG，Korting HC，Pavicic T，et al.Hypertrophic scarring and keloids：pathomechanisms and current and emerging treatment strategies[J].Mol Med，2011，17（1-2）：113-125.
[2]
Wilgus TA，Ferreira AM，Oberyszyn TM，et al.Regulation of scar formation by vascular endothelial growth factor[J].Lab Invest，2008，88（6）：579-590.
[3]
Staton CA，Valluru M，Hoh L，et al.Angiopoietin-1，angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring[J].Br J Dermatol，2010，163（5）：920-927.
[4]
Chappell JC，Bautch VL.Vascular development：genetic mechanisms and links to vascular disease[J].Curr Top Dev Biol，2010，90：43-72.
[8]
Clark JA，Leung KS，Cheng JC，et al.The hypertrophic scar and microcirculation properties[J].Burns，1996，22（6）：447-450.
Rapp SJ，Rumberg A，Visscher M，et al.Establishing a reproducible hypertrophic scar following Thermal injury：a porcine model[J].Plast Reconstr Surg Glob Open，2015，3（2）：e309.
[6]
Namazi MR，Fallahzadeh MK，Schwartz RA.Strategies for prevention of scars：what can we learn from fetal skin?[J].Int J Dermatol，2011，50（1）：85-93.
[7]
Ogawa R.The most current algorithms for the treatment and prevention of hypertrophic scars and keloids reply[J].Plast Reconstr Surg，2010，126（3）：1131-1132.
[9]
Johnson KE，Wilgus TA.Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair[J].Adv Wound Care（New Rochelle），2014，3（10）：647-661.
[11]
Hill LM，Gavala ML，Lenertz LY，et al.Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes[J].J Immunol，2010，185（5）：3028-3034.
[12]
Medhi B，Sewal RK，Kaman L，et al.Efficacy and safety of an advanced formula silicone gel for prevention of postoperative scars[J].Dermatol Ther（Heidelb），2013，3（2）：157-167.
[13]
Kim S，Choi TH，Liu W，et al.Update on scar management：guidelines for treating Asian patients[J].Plast Reconstr Surg，2013，132（6）：1580-1589.
[14]
Lee DW，Ku SK，Cho HJ，et al.Effects of Noscarna on hypertrophic scarring in the rabbit ear model：histopathological aspects[J].Arch Pharm Res，2012，35（11）：1999-2006. [15]Liu Y，Chen JY，Shang HT，et al.Light microscopic，electron microscopic，and immunohistochemical comparison of Bama minipig（Sus scrofa domestica）and human skin[J].Comp Med，2010，60（2）：142-148.
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