Abstract：ObjectiveTo explore the effect of Megadose Meropenem combined with Sulbactam treating pneumonia of multidrug resistant Acinetobacter Bauman.MethodsThe clinical data of 65 patients with pneumonia of multidrug resistant Acinetobacter Bauman treated in our hospital from June 2011 to August 2016 were selected to analyze.They were divided into two groups according to different therapeutic measures.In the control group(n=30),patients were treated by common dose of Meropenem(1.0 g)combined with Sulbactam,while in the observation group(n=35),high-dose of Meropenem(2.0 g)combined with Sulbactam was adopted.Patients were treated for five days.The plasma indexes(PCT,CRP), white blood cell count,clinical effect,and adverse reaction before and after therapy in the two groups were compared.ResultsThe difference of PCT,CRP,WBC count of the two groups before treatment were not statistically significant(P> 0.05),after treatment,PCT,CRP,WBC count in two groups were lower than that before treatment,and PCT,CRP,WBC count after treatment in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).ConclusionThe clinical effect of Megadose Meropenem combined with Sulbactam treating pneumonia of multidrug resistant Acinetobacter Bauman caused by drug resistant Acinetobacter Bauman is obvious,and it has no obvious adverse reactions,it is worthy of clinical promotion and application.
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