精神分裂症患者神经营养因子血清浓度与临床症状相关性研究

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摘要目的研究首发精神分裂症患者脑源性神经营养因子（BDNF）及神经生长因子（NGF）的血清浓度与临床症状的相关性。方法以2015年9月～2016年11月我院早期干预科住院的38例首发精神分裂症患者和50例健康体检者为研究对象，使用酶联免疫吸附法（ELISA）测定BDNF和NGF血清浓度，使用阳性和阴性症状量表（PANSS）评定患者组临床症状，对两组BDNF、NGF血清浓度进行比较，使用Pearson相关分析对患者组PANSS分和BDNF、NGF血清浓度进行相关分析。结果患者组的血清BDNF水平[（2913.19±638.30）pg/ml]显著低于对照组[（3553.05±685.98）pg/ml]（t=4.465，P＜0.01）。患者组的血清NGF水平[（36.96±8.28）pg/ml]显著低于对照组[（44.30± 10.94）pg/ml]（t=3.450，P＜0.01）。患者组BDNF血清浓度与PANSS各项分之间没有相关性；患者组NGF血清浓度与PANSS阴性分成负相关（r=-0.256，P＜0.05），与PANSS总分、阳性分和一般分之间没有相关性；患者组BDNF与NGF血清浓度成正相关（r=0.378，P＜0.01）。结论精神分裂症患者存在认知功能损害，精神分裂症患者血清NGF可能影响神经生长发育；BDNF和NGF在精神分裂症发病机制中所起的作用相似。

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	万静
	黄彩英
	薛坤喜
	胡静
	平军娇
	杜宝国

关键词 ：精神分裂症, 脑源性神经营养因子, 神经生长因子

Abstract：ObjectiveTo study the correlation among brain-derived neurotrophic factor(BDNF),nerve gowth factor(NGF) and the clinical manifestation in first episode schizophrenia.MethodsDouble antibody sandwich enzyme-linked immunosorbentassay(ELISA)was adopted to quantitate BDNF and NGF serum levels of 38 first episode schizophrenic patients hospitalized in Department of Early Intervention of our Hospital from September 2015 to November 2016 and 50 healthy people for medical examinations.Positive and negative syndrome scale(PANSS)was used to evaluate the clinical state of the patients.BNDF and NGF serum concentration of the two groups was analyzed.Pearson correlative analysis was adopted to analyze the correlation between BDNF,NGF serum concentrations and PANSS scores in patient group.ResultsNo statistical differences was found in age,gender or years of education in two groups.Lower BDNF serum levels[(2913.19± 638.30)pg/ml]were found(t=4.465,P＜0.01)in the patient group than in healthy subjects[(355.3±685.98)pg/ml].Lower NGF serum concentrations[(36.96±8.28)pg/ml]were found(t=3.450，P＜0.01)in the patient group than in the controls[(44.30± 10.94)pg/ml].BDNF serum concentrations and PANSS scores were not correlated in patient group.There were no correlations found among,PANSS-positive scores,PANSS-general scores and PANSS-Total scores in the patient group,however, NGF serum levels were negatively related to PANSS-negtive scores in patient group(r=-0.256,P＜0.05).BDNF was found positively related to NGF serum levels(r=0.378,P＜0.01).ConclusionCognitive impairments occurred in schizophrenic patients,and NGF in the serum may impact growth and development of nervous system.BDNF and NGF may play similar role on nosogenesis of schizophrenia.

Key words： Schizophrenia BDNF NGF

引用本文:

万静；黄彩英；薛坤喜；胡静；平军娇；杜宝国. 精神分裂症患者神经营养因子血清浓度与临床症状相关性研究[J]. 中国当代医药, 2017, 24(19): 50-52.
WAN Jing ；HUANG Cai-ying ；XUE Kun-xi；HU Jing； PING Jun-jiao； DU Bao-guo. Research on serum correlation of neurotrophin and clinical symptoms in first episode Schizophrenia. 中国当代医药, 2017, 24(19): 50-52.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I19/50

[1]	Brown AS.The environment and susceptibility to schizophrenia[J].Prog Neurobiol，2011，93（1）：23-58.
[2]	Xiao WH，Ye F，Liu CL，et al.Cognitive impairment in firstepisode drug-naïve patients with schizophrenia:Relationships with serum concentrations of brain-derived.Progress in neurotrophic factor and glial cell line-derived neurotrophic factor[J].Prog Neuropsychopharmacol Biol Psychiat，2017，76（3）：163-168.
[3]	温科奇，牛莉莉，熊鹏，等.血清蛋白因子对精神分裂症首次发病患者的疗效预测[J].临床精神医学杂志，2015，25（6）：365-368.
[4]	Orlova V，Efanova N，Tshcherbakova T，et al.MRI-Peculiari ties of frontal lobes and auto antibodies to nerve growth factor（NGF）in families of patients with schizophrenia[J].Schizophr Res，2008，98（12）：144.
[5]	Kawashima K，Ikeda M，Kishi T，et al.BDNF is not associated with schizophrenia：data from a Japanese population study and meta-analysis[J].Schizophr Res，2009，112（1-3）：72-79.
[6]	Plotkin JL，Wu CB.Neurotrophin biology at NGF 2016：From fundamental science to clinical applications.[J].Int J Dev Neurosci，2017，56（2）：27-34.
[7]	Peng X，Zeng Y，Zhu ZX，et al.Reduced NGF serum levels and abnormal P300 event-related potential in first episode schizophrenia[J].Schizophr Res，2010，119（3）：34-39.
[8]	Jacopo Meldolesi.Neurotrophin receptors in the pathogenesis，diagnosis and therapy of neurodegenerative diseases[J]. Pharmacol Res，2017，121（7）：129-137.
[9]	Zhang XY，Tan YL，Chen DC，et al.Interaction of BDNF with cytokines in chronic schizophrenia[J].Brain Behav Immunl，2016，51（2）：169-175.
[10]	J?nsson EG，Edman-Ahlbom B，Sillén A，et al.Brain-derivedneurotrophicfactorgene（BDNF）variantsandschizophrenia：An association study[J].Prog Neuropsychopharmacol Biol Psychiat，2006，30（5）：924-933.
[11]	Rizos EN，Rontos I，Laskos E，et al.Invest Serum BDNF levels in drug-naive patients with schizophrenia[J].Prog Neuropsychopharmacol Biol Psychiat，2008，32（5）：1308-1311.
[12]	Fatma K，Armagan O，Suat S，et al.The relationship of Chlamydophila pneumoniae with schizophrenia:The role of brainderived neurotrophic factor（BDNF）and neurotrophin-3（NT-3）in this relationship[J].Rev Argent Microbiol，2017，49（1）：39-49.
[13]	Nuria D，Johannes T.Neurotrophic factors and the pathophysiology of schizophrenic psychoses[J].Eur Psychiat，2004，19（2）：326-337.
[14]	Peng X，Zeng Y，Wan J，et al.The role of NGF and IL-2 serum level in assisting t he diagnosis in first episode schizophrenia[J].Psychiat Res，2011，189（1）：72-76.
[15]	Lang UE.，Jockers-Scherubl MC，Hellweg R.State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations[J].J Neural Transm，2004，111（3）：387-411.