Abstract：ObjectiveTo explore the clinical application of chorionic and amniotic fluid puncture in prenatal diagnosis of thalassemia.M ethodsA total of 100 pregnant women with thalassemia were selected from September 18,2015 to September 18,2016 were selected in our hospital,and they were divided into two groups according to different gestational age：the observation group in early pregnancy (＜13 weeks),was given the detection of chorionic biopsy;the control group in themiddle of pregnancy(13-28 weeks),was given the detection of amniotic fluid puncture.After the implement of different detection methods,the total incidence of complications,access to success rate,puncture gestational age,puncture time,test results of thalassemia were compared between the two groups.ResultsThe gestational time [(12.45±0.58)weeks]and the time of puncture [(10.15±0.69)min]were better than those in the control group [(19.45±1.45)weeks,(11.85±0.52)min](P＞0.05);there was no difference in the incidence of beta-severe thalassemia and alpha-severe thalassemia,total complications,success rates between the two groups(P＞0.05).ConclusionThe effect of early pregnancy chorionic biopsy in prenatal diagnosis of pregnant women with thalassemia ismore significant than that ofmid-pregnancy amniotic fluid.
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