Effect of monoclonal antibody and polyclonal antibody on procalcitonin in renal transplantation patients
WANG Si-qi1 CHEN Wen-li2 TAI Qiang1▲
1.Department of Critical Care Medicine,the First Affiliated Hospital of Sun Yat-sen University,Guangdong Province,Guangzhou 510700,China;
2.Department of Neurosurgery,the First Affiliated Hospital of Sun Yat-sen University,Guangdong Province,Guangzhou 510700,China
Abstract：Objective To investigate the effect of monoclonal antibody and polyclonal antibody on procalcitonin in renal transplantation patients.Methods A total of 101 renal transplant patients admitted to the First Affiliated Hospital of Sun Yat-sen University from June 2017 to June 2020 were retrospectively selected as the subjects.According to the immunosuppressive treatment regimen,the patients were divided into monoclonal antibody group(n=50)and polyclonal antibody group (n=51).The monoclonal antibody group was treated with Basiliximab,and the polyclonal group was treated with Anti-human Thymocyte Immunoglobulin.The levels of procalcitonin,creatinine,urea nitrogen were compared between the two groups after renal transplantation.Results There was no significant difference in procalcitonin level between the two groups 1-4 days after operation (P＞0.05).The level of procalcitonin in the polyclonal group was significantly higher than that in the monoclonal group at 5-6 days after operation,with statistical significance(P＜0.05).At 5-7 days after surgery,the level of procalcitonin in both groups was lower than that at 1 day after surgery,with statistical significance (P＜0.05).There were no significant differences in creatinine and urea nitrogen between the two groups at 1-7 days after operation (P＞0.05).At 6-7 days after surgery,creatinine level in both groups was lower than that at 1 day after surgery,with statistical significance (P＜0.05).On day 7 after surgery,the level of urea nitrogen in the two groups was lower than that on day 1 after surgery,the difference was statistically significant(P＜0.05).Conclusion Immunosuppressant can increase procalcitonin.Polyclonal antibodies have a greater effect on the fluctuation of procalcitonin levels than monoclonal antibodies.
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