Abstract：Objective To explore the effect of Midazolam combined with Fentanyl on cerebral metabolism in patients with severe subarachnoid hemorrhage.Methods A total of 40 patients with severe subarachnoid hemorrhage admitted to Fukuang General Hospital of Liaoning Health Industry Group from February 2017 to May 2019 were selected and divided into control group(20 cases)and observation group(20 cases)according to the order of admission.The control group was treated with Dexmedetomidine and the observation group was treated with Midazolam combined with Fentanyl.The richmond agitation-sedation scale(RASS)score,intensive care unit pain observation tool(CPOT)score,and blood oxygen saturation were compared between the two groups.Results The carotid blood oxygen saturation of the observation group was lower than that of the control group 30 minutes after treatment,and the difference was statistically significant(P＜0.05);the jugular venous blood oxygen saturation and central venous blood oxygen saturation of the observation group were higher than those of the control group 30 minutes after treatment,and the differences were statistically significant(P＜0.05);the RASS score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P＜0.05);the CPOT score after treatment between the two groups was not statistically significant(P＞0.05).Conclusion The application of Midazolam combined with Fentanyl for sedation and analgesia in patients with severe subarachnoid hemorrhage can improve brain metabolism and has a good therapeutic effect.
孙可心. 咪达唑仑联合芬太尼对重症蛛网膜下腔出血患者脑代谢的影响[J]. 中国当代医药, 2021, 28(31): 99-102.
SUN Ke-xin. Effect of Midazolam combined with Fentanyl on cerebral metabolism in patients with severe subarachnoid hemorrhage. 中国当代医药, 2021, 28(31): 99-102.
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