Abstract：Objective To explore the application of modified Qinggan Huashi Huoxue Decoction combined with Polyene Phosphatidyl Choline in patients with alcoholic fatty liver.Methods A total of 200 patients with alcoholic fatty liver who were diagnosed and treated in Chest Hospital of Jingzhou City,Hubei Province from November 2017 to November 2019 were selected as the study objects.The patients were divided into the study group and the control group by random number table method,with 100 cases in each group.The control group was treated with Polyene Phosphatidyl Choline,and the study group was treated with modified Qinggan Huashi Huoxue Decoction on the basis of the control group.Therapeutic effect,liver function indexes(alanine aminotransferase[ALT],aspartate aminotransferase[AST]and γ-glutamine transpeptidase[GGT]),blood lipid level(total cholesterol[TC],triglyceride[TG]),serum fibrinogen protein 1(FLP1),type Ⅲprocollagen peptide(PⅢP)level were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of ALT,AST,GGT,TC and TG in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the FLP1 in the study group was higher than that in the control group,and the PⅢP was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Modified Qinggan Huashi Huoxue Decoction combined with Polyene Phosphatidyl Choline is effective in the treatment of alcoholic fatty liver.It can obviously improve the metabolism of blood lipid and liver function,and reduce the degree of liver fibrosis.
Ma C，Zhang W，Yang X，et al.Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient micea new antiatherogenic strategy[J].Br J Pharmacol，2018，175（9）：1486-1503.
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